Bisindolylmaleimide IX (BIM IX) is a potent, cell-permeable inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-alpha, PKC-betaI, PKC-betaII, PKC-gamma, and PKC-epsilon, respectively). It is a poor inhibitor of protein kinase A (PKA, IC50 = 0.9 µM) and calcium/calmodulin kinase II...

An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John's wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts...

PGDM-d4 is intended for use as an internal standard for the quantification of PGDM by GC- or LC-MS. PGD2 plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle. PGDM...

Goat anti-mouse IgG conjugated to SureLight(R) P3 Antibody: Goat polyclonal anti-Mouse IgG Dye: SureLight(R) P3 Excitation max. lambda: 614 nm Emission max. lambda: 662 nm Isotype: IgG Uses: Flow cytometry, fluorescence-activated cell sorting, and protein microarraysEmission: 662 nm. Excitation: 614 nm. Formulation:...