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CGP 57380
CGP 57380

Item number: Cay13322-25

CGP 57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro (IC50 = 2.2 µM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. It blocks the phosphorylation of eIF4E in response to TNF-alpha, arsenite, anisomycin, PMA, or fetal calf serum in 293 cells (IC50 =...
Keywords: MNK1 Inhibitor, N3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
Application: MAPK-interacting kinase 1 inhibitor
CAS 522629-08-9
MW: 244.2 D
From 60.00€ *
Review
Fumagillin
Fumagillin

Item number: Cay11332-5

Fumagillin is a fungal metabolite that has been found in A. fumigatus and has diverse biological activities. It inhibits methionyl aminopeptidase 2 (METAP2, IC50 = 10 nM). Fumagillin (10 ng/ml) inhibits tube formation in a rat blood vessel organ culture assay. It inhibits E. cuniculi replication in isolated rabbit...
Keywords: Amebacilin, NSC 9168, 2E,4E,6E,8E-decatetraenedioic acid,...
Application: Angiogenesis inhibitor, metabolic studies
CAS 23110-15-8
MW: 458.6 D
From 129.00€ *
Review