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Cay13332-1
CAS: 913844-​45-​8
ROCK inhibitor Erklärungen der Abkürzungen ansehen.
Two Rho kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits calcium/calmodulin kinase II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 µM, respectively) as well as PKA or PKC (IC50 >10 µM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM).

MW: 449 D
Formula: C18H24N4O3S . 2HCl
Purity: >98%
Cayman
Icon Datasheet
1 mg

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166 €

Cay13332-5
CAS: 913844-​45-​8
ROCK inhibitor Erklärungen der Abkürzungen ansehen.
Two Rho kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits calcium/calmodulin kinase II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 µM, respectively) as well as PKA or PKC (IC50 >10 µM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM).

MW: 449 D
Formula: C18H24N4O3S . 2HCl
Purity: >98%
Cayman
Icon Datasheet
5 mg

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696 €

Cay13332-500
CAS: 913844-​45-​8
ROCK inhibitor Erklärungen der Abkürzungen ansehen.
Two Rho kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits calcium/calmodulin kinase II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 µM, respectively) as well as PKA or PKC (IC50 >10 µM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM).

MW: 449 D
Formula: C18H24N4O3S . 2HCl
Purity: >98%
Cayman
Icon Datasheet
500 µg

Buy Bulk

87 €


 

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