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(S)-Glycyl-H-1152 (hydrochloride) | CAS 913844-45-8

ART NR.: Cay13332-500 (500 µg)
Cay13332-1 (1 mg)
Cay13332-5 (5 mg)

Hersteller: Cayman



Anwendungen: ROCK inhibitor

CAS-Nr. : 913844-​45-​8 | Suche mit CAS-Nr.

MW: 449 D

Formel: C18H24N4O3S . 2HCl

Reinheit: >98%

Format: solution

Lagerung: -20°C

Versand: +20°C

KEGG ID: K04514 | Suche mit KEGG ID

Schlagworte: 2-amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]-ethanone, dihydrochloride


500 µg

97 €


1 mg

181 €


5 mg

743 €

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Bemerkungen: Two Rho kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits better specificity. Thus, it poorly inhibits calcium/calmodulin kinase II, protein kinase (PK) G, and Aurora A (IC50 = 2.57, 2.35, and 3.26 µM, respectively) as well as PKA or PKC (IC50 >10 µM for each). The potency of Glycyl-H-1152 is superior to that of other ROCK inhibitors, including Y-27632 (Ki = 220 nM) and HA-1077 (IC50 = 158 nM).

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