- Search results for Cay13330
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12 products were found matching "Cay13330"!
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Item number: Cay13330-10
1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28...
Keywords: | PP1 Analog II, 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
Application: | Analog-sensitive kinase inhibitor |
CAS | 221244-14-0 |
MW: | 331.4 D |
From 95.00€
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Item number: Cay11330-1
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...
Keywords: | NSC 209835,... |
Application: | Cell-permeable actin polymerization inhibitor |
CAS | 22144-77-0 |
MW: | 507.6 D |
From 83.00€
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Item number: Cay13000-100
Pterostilbene is a polyketide synthase-derived stilbene originally isolated from P. santalinus that has diverse biological activities. It reduces photooxidative leakage induced by the herbicide acifluorfen in C. sativus cotyledon disks when used at a concentration of 30 µg/ml. Pterostilbene (25 and 50 µM) inhibits...
Keywords: | trans-3,5-Dimethoxy-4'-Hydroxystilbene, 3',5'-Dimethoxy-4-Stilbenol, 4-[(1E)-2-(3,5-dimethoxyphenyl)ethenyl)-phenol |
Application: | Antioxidant |
CAS | 537-42-8 |
MW: | 256.3 D |
From 74.00€
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Item number: Cay11300-100
Methylation of lysine residues in core histones plays a critical role in regulating gene expression. Jumonji domain containing 2D (JMJD2D) catalyzes the demethylation of di- and tri-methylated forms of histone H3 at lysine residue 9 (me 2/3), leading to transcriptional repression and activation, respectively. Like...
Keywords: | KDM4D, JHDM3D, Lysine-specific demethylase 4D, Lysine-specific demethylase 4D, Jumonji domain-containing protein 2D,... |
Application: | Enzyme activity, WB |
Expressed in: | E.coli |
MW: | 42,6 kD |
642.00€
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Item number: Cay13300-10
Bisindolylmaleimide V (BIM V) is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 µM. While effectively inactive as a PKC inhibitor, BIM V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM.Formal Name:...
Keywords: | BIM V, Ro 31-6045, 3,4-di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione |
Application: | S6K inhibitor |
CAS | 113963-68-1 |
MW: | 341.4 D |
From 86.00€
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Item number: Cay13336-10
CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene alpha (Gro-alpha, CXCL1). IL-8 and Gro-alpha are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB...
Keywords: | N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-urea |
Application: | CXCR2 antagonist |
CAS | 182498-32-4 |
MW: | 352.1 D |
From 110.00€
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Item number: Cay13334-10
Bisindolylmaleimide IX (BIM IX) is a potent, cell-permeable inhibitor of protein kinase C (PKC) isoforms (IC50 = 5, 24, 14, 27, and 24 nM for PKC-alpha, PKC-betaI, PKC-betaII, PKC-gamma, and PKC-epsilon, respectively). It is a poor inhibitor of protein kinase A (PKA, IC50 = 0.9 µM) and calcium/calmodulin kinase II...
Keywords: | BIM IX, Ro 31-8220, carbamimidothioic acid,... |
Application: | PKC inhibitor |
CAS | 138489-18-6 |
MW: | 553.7 D |
From 60.00€
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Item number: Cay13338-10
The Src family of proto-oncogenic kinases include nine mammalian non-receptor tyrosine kinases that are involved in intracellular signaling and are often relevant to carcinogenesis. SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). It weakly...
Keywords: | 2,3-dihydro-N,N-dimethyl-2-oxo-3-[(4,5,6,7-tetrahydro-1H-indol-2-yl)methylene]-1H-indole-5-sulfonamide |
Application: | Src kinase inhibitor |
CAS | 330161-87-0 |
MW: | 371.5 D |
From 32.00€
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Item number: Cay13339-10
SQ 22,536 is an inhibitor of adenylyl cyclase with an IC50 value of 13 µM for inhibition of prostaglandin E1-stimulated increase in cAMP in intact platelets. It has been used to evaluate adenylyl cyclase activity during iloprost-induced vasorelaxation of isolated pulmonary veins or aorta in several research...
Keywords: | NSC 53339, 9-(tetrahydro-2-furanyl)-9H-purin-6-amine |
Application: | Adenylyl cyclase inhibitor |
CAS | 17318-31-9 |
MW: | 205.2 D |
From 84.00€
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Item number: Cay13332-10
Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent...
Keywords: | Rho Kinase Inhibitor IV,... |
Application: | ROCK inhibitor |
CAS | 913844-45-8 |
MW: | 449.4 D |
From 125.00€
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Item number: Cay13333-10
Bisindolylmaleimide VIII (BIM VIII) is a selective protein kinase C (PKC) inhibitor (IC50 = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. This compound exhibits some degree of PKC isozyme specificity with preference for PKCalpha over PKCbetaI, PKCbetaII, PKCgamma, or PKCepsilon (IC50s = 53,...
Keywords: | BIM VIII, Ro 31-7549, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, acetate |
Application: | PKC inhibitor |
CAS | 138516-31-1 |
MW: | 458.5 D |
From 68.00€
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Item number: Cay13337-10
ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-alpha and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.Formal Name: 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide. CAS...
Keywords: | 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide |
Application: | Tyrosine kinase inhibitor |
CAS | 107761-24-0 |
MW: | 354.4 D |
From 52.00€
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