- Search results for Cay13305
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13 products were found matching "Cay13305"!
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Item number: Cay13305-5
D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1, IC50 = 200 nM from S. pombe, 300 nM for CK1delta). It is a less effective inhibitor of PKD1 (IC50 = 9.1 µM) and p38alpha MAPK (IC50 = 5.8 µM), and only weakly affects the activities of a panel of kinases tested. D 4476 blocks CK1-mediated phosphorylation...
Keywords: | Casein Kinase I Inhibitor, 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl)1H-imidazol-2-yl]-benzamide |
Application: | CK1 inhibitor |
CAS | 301836-43-1 |
MW: | 398.4 D |
From 34.00€
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Item number: Cay13330-5
1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28...
Keywords: | PP1 Analog II, 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
Application: | Analog-sensitive kinase inhibitor |
CAS | 221244-14-0 |
MW: | 331.4 D |
From 95.00€
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Item number: Cay11330-5
The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...
Keywords: | NSC 209835,... |
Application: | Cell-permeable actin polymerization inhibitor |
CAS | 22144-77-0 |
MW: | 507.6 D |
From 83.00€
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Item number: Cay13300-5
Bisindolylmaleimide V (BIM V) is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 µM. While effectively inactive as a PKC inhibitor, BIM V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM.Formal Name:...
Keywords: | BIM V, Ro 31-6045, 3,4-di-1H-indol-3-yl-1-methyl-1H-pyrrole-2,5-dione |
Application: | S6K inhibitor |
CAS | 113963-68-1 |
MW: | 341.4 D |
From 86.00€
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Item number: Cay11305-50
L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR, Kd = ~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in...
Keywords: | 3-anthraniloyl-Alanine, alphaS,2-diamino-gamma-oxo-benzenebutanoic acid |
Application: | AHR ligand |
CAS | 2922-83-0 |
MW: | 208.2 D |
From 50.00€
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Item number: Cay13055-5
Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 µM). It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP),...
Keywords: | CCG 8295, 3,11-dihydroxy-spiro[7H-dibenzo[c,h]xanthene-7,1'(3'H)-isobenzofuran]-3'-one |
Application: | Furin inhibitor |
CAS | 61419-02-1 |
MW: | 432.4 D |
From 43.00€
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Item number: Cay13005-250
4-Pyridylamide oxime is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: N-hydroxy-4-pyridinecarboximidamide. CAS Number: 1594-57-6. Synonyms: NSC 43969. Molecular Formula: C6H7N3O. Formula Weight: 137.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid....
Keywords: | NSC 43969, N-hydroxy-4-pyridinecarboximidamide |
Application: | Synthetic intermediate, Pharmaceutical synthesis |
CAS | 1594-57-6 |
MW: | 137.1 D |
From 22.00€
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Item number: Cay13308-5
DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230...
Keywords: | DNA-PK Inhibitor II, LY293646, 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one |
Application: | DNA-PK inhibitor |
CAS | 154447-35-5 |
MW: | 281.3 D |
From 109.00€
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Item number: Cay13302-5
DNA methylation regulates gene expression in normal and malignant cells. RG108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 µM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like...
Keywords: | N-Phthalyl-L-Tryptophan, alpha-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-(alphaS)-1H-indole-3-propanoic acid |
Application: | DNA methyltransferase inhibitor |
CAS | 48208-26-0 |
MW: | 334.3 D |
From 84.00€
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Item number: Cay13303-5
Three genes encode dual specificity phosphatases that are Cdc25 homologs. The phosphatases, Cdc25A through C, are proto-oncogenes and are often over-expressed in cancers. NSC 663284 is a potent, cell-permeable, and irreversible inhibitor of all Cdc25 isoforms, with preference for Cdc25A (IC50 = 29, 95, and 89 nM for...
Keywords: | Cdc25 Phosphatase Inhibitor II, DA-3003-1, SPS8I1, 6-chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione |
Application: | Cdc25 inhibitor |
CAS | 383907-43-5 |
MW: | 321.8 D |
From 32.00€
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Item number: Cay13304-5
Biotin-XX hydrazide is a biotylating reagent for carbohydrates and carbonyl compounds that contains two aminohexanoic spacers to increase the efficiency of avidin-binding by alleviating steric hindrance.Formal Name:...
Keywords: | 6-[[6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxohexyl]amino]-hexanoic acid... |
Application: | Biotinylation |
CAS | 211237-33-1 |
MW: | 484.7 D |
From 88.00€
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Item number: Cay13307-5
D609 is a xanthate and a competitive inhibitor of phosphatidylcholine-specific phospholipase C (PC-PLC, Ki = 6.4 µM). It has no effect on bacterial phosphatidylinositol-specific PLC, bovine pancreatic PLA2, or phospholipase D. D609 reduces sphingomyelin synthase activity by 55.5 and 90.5% in membrane preparations...
Keywords: | Tricyclodecan-9-yl xanthogenate, O-(octahydro-4,7-methano-1H-inden-5-yl) ester, carbonodithioic acid, monopotassium salt |
Application: | PC-PLC inhibitor |
CAS | 83373-60-8 |
MW: | 266.5 D |
From 50.00€
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