10 products were found matching "Cay13295"!

No results were found for the filter!
HNHA
HNHA

Item number: Cay13295-5

HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity (IC50 = 100 nM). In human fibrosarcoma HT1080 cells, it induces histone hyperacetylation and p21 transcription with concomitant inhibition of cell cycle progression (IC50 ~7.5 µM). HNHA is at least as effective as SAHA in inhibiting tumor...
Keywords: Histone Deacetylase Inhibitor VI, N-hydroxy-7-(2-naphthalenylthio)-heptanamide
Application: HDAC inhibitor
CAS 926908-04-5
MW: 303.4 D
From 114.00€ *
Review
Cytochalasin C
Cytochalasin C

Item number: Cay11329-5

Cytochalasin C is an actin polymerization inhibitor and fungal metabolite that has been found in C. globosum. It inhibits actin polymerization when used at a concentration of 10 µM. Cytochalasin C is cytotoxic to HeLa cells (IC50 = 99%. Formulation: (Request formulation change), A powder. Solubility: DMF: soluble,...
Keywords: (3S,3aR,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(acetyloxy)-3,3a,6,6a,9,10,12,15-octahydro-6,12-dihydroxy-4,5,10,12-tetramethyl...
Application: Actin polymerization inhibitor
CAS 22144-76-9
MW: 507.6 D
From 130.00€ *
Review
Bisindolylmaleimide IV
Bisindolylmaleimide IV

Item number: Cay13299-5

Bisindolylmaleimide IV (BIM IV) is a cell permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM. BIM IV was designed to be more discriminative than its parent compound, the non-selective PKC inhibitor, staurosporine (Cay-81590). However, BIM IV also inhibits protein...
Keywords: Arcyriarubin A, BIM IV, 3,4-di-1H-indol-3-yl-1H-pyrrole-2,5-dione
Application: PKC inhibitor
CAS 119139-23-0
MW: 327.3 D
From 72.00€ *
Review
thio-p-Toluamide
thio-p-Toluamide

Item number: Cay13229-5

thio-p-Toluamide is a cyclic thioamide building block used in drug discovery chemistry.Formal Name: 4-methyl-benzenecarbothioamide. CAS Number: 2362-62-1. Synonyms: 4-Methylbenzenethioamide. Molecular Formula: C8H9NS. Formula Weight: 151.2. Purity: >98%. Formulation: (Request formulation change), A crystalline...
Keywords: 4-Methylbenzenethioamide, 4-methyl-benzenecarbothioamide
Application: Drug discovery, Building block
CAS 2362-62-1
MW: 151.2 D
From 23.00€ *
Review
PD 158780
PD 158780

Item number: Cay13329-5

PD 158780 is a pyridopyrimidine derivative that reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor tyrosine kinase superfamily: EGFR (IC50 = 8 µM), ErbB2 (IC50 = 49 nM), ErbB3, and ErbB4 (IC50 = 52 nM). It does not inhibit PDGF or FGF-mediated tyrosine phosphorylation. At 0.5...
Keywords: N4-(3-bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine
Application: EGFR / erbB2 / erbB3 / erbB4 inhibitor
CAS 171179-06-9
MW: 330.2 D
From 50.00€ *
Review
Bisindolylmaleimide I
Bisindolylmaleimide I

Item number: Cay13298-5

Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine (Cay-81590). It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCalpha,...
Keywords: BIM I, GF 109203X, Gö 6850, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Application: PKC inhibitor
CAS 133052-90-1
MW: 412.5 D
From 115.00€ *
Review
AG-126
AG-126

Item number: Cay13297-5

Tyrphostins are a family of protein tyrosine kinase inhibitors originally developed to inhibit cell growth by blocking the activity of certain growth factor receptor kinases (GFRK). The tyrphostin AG-126 selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 µM. It blocks the production of...
Keywords: Tyrphostin AG-126, 2-[(3-hydroxy-4-nitrophenyl)methylene]-propanedinitrile
Application: ERK inhibitor
CAS 118409-62-4
MW: 215.2 D
From 35.00€ *
Review
Rhapontigenin
Rhapontigenin

Item number: Cay13293-5

Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. It is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50 = 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. At higher concentrations,...
Keywords: 5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol
Application: Resveratrol analog, Antioxidant, Selective CYP1A1 inactivator
CAS 500-65-2
MW: 258.3 D
From 119.00€ *
Review
CAY10616
CAY10616

Item number: Cay13291-5

Resveratrol is a natural polyphenolic antioxidant that has anti-cancer properties. CAY10616 is an analog of resveratrol which potently induces apoptosis in promyelocytic leukemia HL-60 cells (IC50 = 40 nM, vs. 50 µM for resveratrol). In addition, CAY10599 induces apoptosis (IC50 = 30 nM) in HL-60R, a cell line...
Keywords: 5-[(1Z)-2-(3,5-dimethoxyphenyl)ethenyl]-2-methoxy-phenol
Application: Resveratrol analog
CAS 586410-08-4
MW: 286.3 D
From 38.00€ *
Review
Pyrrophenone
Pyrrophenone

Item number: Cay13294-5

The group IVA phospholipase A2 (PLA2), known as calcium-dependent cytosolic PLA2 (cPLA2), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA2alpha with an IC50 of 4.2 nM...
Keywords: N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-[(triphenylmethyl)thio]-2-pyrrolidinyl]methyl]-4-[(Z)-(2,4-dioxo-5-thiazo...
Application: cPLA2 inhibitor
CAS 341973-06-6
MW: 850 D
From 164.00€ *
Review