- Search results for Cay13282-%25
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10 products were found matching "Cay13282-%25"!
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Item number: Cay13288-25
Itraconazole is an antifungal agent and inhibitor of hedgehog signaling (IC50 = 800 nM). It binds to 14-alpha sterol demethylase/CYP51 isoform B (AF51B, Kd = 31 nM for A. fumigatus enzyme expressed in E. coli) and inhibits ergosterol biosynthesis in C. neoformans (IC50 = 6 nM after a 16-hour incubation). It inhibits...
Keywords: | 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl... |
Application: | Hedgehog signaling antagonist |
CAS | 84625-61-6 |
MW: | 705.6 D |
From 40.00€
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Item number: Cay13284-25
MS-275 is an inhibitor of histone deacetylases (HDACs) that preferentially inhibits HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 µM). However, it does not inhibit HDAC8 (IC50 > 100 µM). MS-275 induces cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1), slowing cell growth, differentiation, and tumor development in...
Keywords: | Entinostat, SNDX 275, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-carbamic acid, 3-pyridinylmethyl ester |
Application: | HDAC inhibitor |
CAS | 209783-80-2 |
MW: | 376.4 D |
From 28.00€
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Item number: Cay13287-25
FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+ depletion. In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM). In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that...
Keywords: | K 22.175, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide |
Application: | NAMPT inhibitor |
CAS | 658084-64-1 |
MW: | 391.5 D |
From 35.00€
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Item number: Cay13268-25
Farnesyl alcohol is an isoprenoid that has been found in aromatic plants and has diverse biological activities. It is an agonist of peroxisome proliferator-activator receptor alpha (PPARalpha) and PPARgamma (EC50s = 5.5 and 28 µM, respectively, in a reporter assay using CV-1 cells) and increases the expression of...
Keywords: | Farnesol, FCI 119a, NSC 60597, 3,7,11-trimethyl-2,6,10-dodecatrien-1-ol |
Application: | Bioactive isoprenoid |
CAS | 4602-84-0 |
MW: | 222.4 D |
From 99.00€
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Item number: Cay13248-25
L-DOPA is a metabolic precursor of dopamine that is capable of crossing the blood-brain barrier. It is produced from L-tyrosine by tyrosine hydroxylase and metabolized by catechol-O-methyl transferase (COMT). In the brain L-DOPA is converted to dopamine. Formulations containing L-DOPA have been used in stroke...
Keywords: | 3,4-Dihydroxyphenylalanine, Levodopa, 3-hydroxy-L-tyrosine |
Application: | Neuropharmacological agent |
CAS | 59-92-7 |
MW: | 197.2 D |
From 26.00€
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Item number: Cay13298-25
Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine (Cay-81590). It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCalpha,...
Keywords: | BIM I, GF 109203X, Gö 6850, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione |
Application: | PKC inhibitor |
CAS | 133052-90-1 |
MW: | 412.5 D |
From 115.00€
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Item number: Cay13212-25
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases (HDACs). Unlike the HDAC inhibitor suberoylanilide hydroamic acid, which has a fast-on/fast-off HDAC binding rate, pimelic diphenylamide 106 progressively binds HDACs and remains bound after wash-out. As a result, the IC50...
Keywords: | Histone Deacetylase Inhibitor VII, TC-H 106, N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide |
Application: | HDAC 1 inhibitor |
CAS | 937039-45-7 |
MW: | 339.4 D |
From 35.00€
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Item number: Cay11238-25
H2S Donor 5a is a stable, cysteine-activated H2S donor. In the presence of excess of cysteine, the concentration of H2S released from this compound reaches a maximum value at 18 min. It does not react with potential cellular nucleophiles such as -OH and -NH2 groups.Formal Name: benzenecarbothioic acid,...
Keywords: | N-(Benzoylthio)benzamide, benzenecarbothioic acid, S-(benzoylazanyl) ester |
Application: | Stable, cysteine-activated H2S donor |
CAS | 134861-13-5 |
MW: | 257.3 D |
From 44.00€
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Item number: Cay16238-25
BIX02188 is a potent inhibitor of MEK5 (IC50 = 4.3 nM) with reduced activity towards inhibition of ERK5 and TGFbetaR1 (IC50s = 810 and 1,800 nM, respectively). It does not inhibit the closely related kinases MEK1, MEK2, ERK2, and JNK2 (IC50s = > 6,300 nM). BIX02188 inhibits phosphorylation of ERK5 in a...
Keywords: | (3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide |
Application: | MEK5 inhibitor |
CAS | 334949-59-6 |
MW: | 412.5 D |
From 60.00€
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Item number: Cay32821-25
4-HQN is a heterocyclic building block. It has been used in the synthesis of compounds with antimalarial or antimicrobial activities in vitro.Formal Name: 4(3H)-quinazolinone. CAS Number: 491-36-1. Synonyms: 4-Hydroxyquinazoline. Molecular Formula: C8H6N2O. Formula Weight: 146.1. Purity: >97%. Formulation: (Request...
Keywords: | 4-Hydroxyquinazoline, 4(3H)-quinazolinone |
Application: | Heterocyclic building block |
CAS | 491-36-1 |
MW: | 146.1 D |
From 77.00€
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