8 products were found matching "Cay13237-%25"!

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Eltrombopag
Eltrombopag

Item number: Cay13247-25

Eltrombopag is an orally bioavailable nonpeptide agonist of the thrombopoietin receptor (EC50 = 0.27 µM in a reporter assay) and an iron chelator. It increases STAT5 phosphorylation in N2C-Tpo cells when used at a concentration of 30 µM and p42/44 MAPK phosphorylation when used at 10 µM. Eltrombopag binds to the...
Keywords: SB 497115,...
Application: TpoR agonist
CAS 496775-61-2
MW: 442.5 D
From 43.00€ *
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CAY10594
CAY10594

Item number: Cay13207-25

Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are...
Keywords: N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide
Application: PLD2 inhibitor
CAS 1130067-34-3
MW: 428.5 D
From 68.00€ *
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MF63
MF63

Item number: Cay13217-25

Microsomal prostaglandin E2 synthase-1 (mPGES-1) is the terminal enzyme in the biosynthesis of PGE2. MF63 is a potent, selective, and orally active inhibitor of human mPGES-1 (IC50 = 1.3 nM). It displays greater than 1,000-fold selectivity over other prostanoid synthases. MF63 also potently inhibits guinea pig...
Keywords: 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile
Application: mPGES-1 inhibitor
CAS 892549-43-8
MW: 378.8 D
From 46.00€ *
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FK-866
FK-866

Item number: Cay13287-25

FK-866 is a highly specific non-competitive inhibitor of Nampt (Ki = 0.4 nM), causing gradual NAD+ depletion. In HepG2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM). In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that...
Keywords: K 22.175, N-[4-(1-benzoyl-4-piperidinyl)butyl]-3-(3-pyridinyl)-2E-propenamide
Application: NAMPT inhibitor
CAS 658084-64-1
MW: 391.5 D
From 35.00€ *
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7-fluoro Tryptamine (hydrochloride)
7-fluoro Tryptamine (hydrochloride)

Item number: Cay17323-25

7-fluoro Tryptamine is a tryptamine derivative that potentially agonizes 5-HT serotonin receptors. Although the biological effects of this compound have not been reported, certain hallucinogenic typtamines containing a fluorine substitution at the 5-, 6-, or 7-position have been shown to have 5-HT2C receptor...
Keywords: 7-fluoro-1H-indole-3-ethanamine, monohydrochloride
Application: Analytical reference standard, Tryptamine derivative, Potential 5-HT2C agonist
CAS 159730-09-3
MW: 214.7 D
From 43.00€ *
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MLN4760
MLN4760

Item number: Cay31327-25

MLN4760 is an inhibitor of angiotensin-converting enzyme 2 (ACE2, IC50 = 0.44 nM). It is selective for ACE2 over ACE and carboxypeptidase A (CPDA, IC50s = >100 and 27 µM, respectively). MLN4760 inhibits ACE2 hydrolysis of angiotensin I in vitro when used at a concentration of 1 µM. It also inhibits the...
Keywords: GL-1001, N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine
Application: ACE2 inhibitor
CAS 305335-31-3
MW: 428.3 D
From 129.00€ *
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ST638
ST638

Item number: Cay13337-25

ST638 is a tyrosine kinase inhibitor (IC50 = 370 nM). It suppresses tyrosine phosphorylation induced by tumor necrosis factor-alpha and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts.Formal Name: 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide. CAS...
Keywords: 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(5-phenylthio)methyl]phenyl]-2-propenamide
Application: Tyrosine kinase inhibitor
CAS 107761-24-0
MW: 354.4 D
From 52.00€ *
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UNC3866
UNC3866

Item number: Cay19237-25

UNC3866 is an inhibitor of chromobox homolog 7 (CBX7, Kd = 97 nM). It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 µM). UNC3866 pretreatment (30 µM) of PC3 lysates completely inhibits...
Keywords: N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine, methyl ester
Application: CBX4 & CBX7 chromodomain antagonist
CAS 1872382-47-2
MW: 795 D
From 65.00€ *
Review