- Search results for Cay13221
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11 products were found matching "Cay13221"!
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Item number: Cay13221-1
3-hexanoyl-NBD cholesterol is a fluorescently tagged cholesterol derivative with the hydrophilic NBD fluorophore attached to carbon 3, at the hydrophilic end of cholesterol, separated by a 6-carbon spacer. This design allows the cholesterol to properly orient in membrane bilayers while the fluorescent tag is...
Keywords: | 3-C6-NBD Cholesterol, 6-[(7-nitro-2,1,3-benzoxadial-4-yl)amino]-cholest-5-en-3-ol |
Application: | Bioactive lipid assays |
CAS | 201731-19-3 |
MW: | 662.9 D |
From 114.00€
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Item number: Cay13222-1
2-Acetyl-5-tetrahydroxybutyl imidazole (THI) is an inhibitor of sphingosine-1-phosphate (S1P) lyase in vivo. THI is not active at S1P lyase in cell-free or cell-based assays but is converted to A6770 in vivo, which is subsequently activated by phosphorylation. In mice, THI (50 µg/ml in drinking water) increases S1P...
Keywords: | 2-Acetyl-4-tetrahydroxybutyl Imidazole, 2-ATHBI, THI, 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]-ethanone |
Application: | S1P lyase inhibitor |
CAS | 94944-70-4 |
MW: | 230.2 D |
From 86.00€
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Item number: Cay13322-1
CGP 57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro (IC50 = 2.2 µM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. It blocks the phosphorylation of eIF4E in response to TNF-alpha, arsenite, anisomycin, PMA, or fetal calf serum in 293 cells (IC50 =...
Keywords: | MNK1 Inhibitor, N3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine |
Application: | MAPK-interacting kinase 1 inhibitor |
CAS | 522629-08-9 |
MW: | 244.2 D |
From 60.00€
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Item number: Cay13332-1
Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent...
Keywords: | Rho Kinase Inhibitor IV,... |
Application: | ROCK inhibitor |
CAS | 913844-45-8 |
MW: | 449.4 D |
From 125.00€
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Item number: Cay11332-1
Fumagillin is a fungal metabolite that has been found in A. fumigatus and has diverse biological activities. It inhibits methionyl aminopeptidase 2 (METAP2, IC50 = 10 nM). Fumagillin (10 ng/ml) inhibits tube formation in a rat blood vessel organ culture assay. It inhibits E. cuniculi replication in isolated rabbit...
Keywords: | Amebacilin, NSC 9168, 2E,4E,6E,8E-decatetraenedioic acid,... |
Application: | Angiogenesis inhibitor, metabolic studies |
CAS | 23110-15-8 |
MW: | 458.6 D |
From 129.00€
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Item number: Cay11321-10
Cyclopamine is a natural steroidal alkaloid that inhibits signaling through the hedgehog pathway at the level of the pathway activator Smoothened. By altering gene expression in this signaling sequence, cyclopamine induces defects in morphogenesis, first observed in chicks and sheep as cyclopia. As a readout of...
Keywords: | 11-Deoxojervine, Jervine,... |
Application: | Pax7 inhibitor |
CAS | 4449-51-8 |
MW: | 411.6 D |
From 31.00€
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Item number: Cay13321-5
Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. During cancer progression both MMP-2 and MMP-9 play a role in metastatic tumor dispersion and angiogenesis. ARP 100 is a...
Keywords: | Matrix Metalloproteinase-2 Inhibitor III, CAY10609, MMP-2 Inhibitor III,... |
Application: | MMP-2 inhibitor |
CAS | 704888-90-4 |
MW: | 364.4 D |
From 39.00€
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Item number: Cay13227-1
Fumonisin B2 (FB2) is a mycotoxin that has been found in F. moniliforme. It is cytotoxic against a panel of seven rat hepatoma cell lines (IC50s = 3-50 µg/ml), as well as MDCK cells (IC50 = 2 µg/ml). FB2 (125-1,000 µM) is also cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of...
Keywords: | FB2,... |
Application: | Apoptosis inducer |
CAS | 116355-84-1 |
MW: | 705.8 D |
From 163.00€
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Item number: Cay13220-1
C-12 NBD cholesterol is a fluorescently tagged cholesterol with the hydrophilic NBD fluorophore attached to the hydrophilic end of cholesterol, separated by a 12-carbon spacer. This design allows the cholesterol to properly orient in membrane bilayers while the fluorescent tag is presented outside of the bilayer....
Keywords: | 3-C12-NBD Cholesterol,... |
Application: | Bioactive lipid assays |
CAS | 1246303-05-8 |
MW: | 747.1 D |
From 114.00€
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Item number: Cay13229-1
thio-p-Toluamide is a cyclic thioamide building block used in drug discovery chemistry.Formal Name: 4-methyl-benzenecarbothioamide. CAS Number: 2362-62-1. Synonyms: 4-Methylbenzenethioamide. Molecular Formula: C8H9NS. Formula Weight: 151.2. Purity: >98%. Formulation: (Request formulation change), A crystalline...
Keywords: | 4-Methylbenzenethioamide, 4-methyl-benzenecarbothioamide |
Application: | Drug discovery, Building block |
CAS | 2362-62-1 |
MW: | 151.2 D |
From 23.00€
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Item number: Cay13122-1
CHIR99021 is an aminopyrimidine derivative that inhibits GSK3alpha and GSK3beta with IC50 values of 10 and 6.7 nM, respectively. When tested against twenty different protein kinases, this inhibitor shows greater than 500-fold selectivity for GSK3. CHIR99021 activates glycogen synthesis in CHO-IR cells (EC50 = 0.763...
Keywords: | CT 99021,... |
Application: | GSK3alpha and GSK3beta inhibitor |
CAS | 252917-06-9 |
MW: | 465.3 D |
From 43.00€
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