- Search results for Cay13181
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7 products were found matching "Cay13181"!
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Item number: Cay13118-1
Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...
Keywords: | 1,1-Dimethylbiguanide hydrochloride, N,N-dimethyl-imidodicarbonimidic diamide, monohydrochloride |
Application: | AMPK activator |
CAS | 1115-70-4 |
MW: | 165.6 D |
From 31.00€
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Item number: Cay13181-1
Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. Three primary types of PLA2 exist: secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2). Of these...
Keywords: | 4-[(1-oxo-7-phenylheptyl)amino]-(4R)-octanoic acid |
Application: | sPLA2 inhibitor |
CAS | 1101136-50-8 |
MW: | 347.5 D |
From 50.00€
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Item number: Cay13318-1
KN-62 is a selective, cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII, IC50 = 900 nM). It does not affect the activity of several other kinases when tested at 10 µM. KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM).Formal Name:...
Keywords: | 5-isoquinolinesulfonic acid,... |
Application: | CAMKII inhibitor |
CAS | 127191-97-3 |
MW: | 721.9 D |
From 66.00€
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Item number: Cay13188-1
Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin and potentiates the procoagulation process by activating factors V, VIII, XI, and XIII. Conversely, thrombin aids the anticoagulant process by activating protein C. Activated protein C inhibits activated factors V and VIII...
Keywords: | Activated Factor II [IIa] |
Application: | Thrombin mediated signaling studies |
MW: | 38,0 kD |
From 205.00€
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Item number: Cay13183-1
Phosphodiesterases (PDE) enzymatically convert the cyclic nucleotide second messengers cAMP and cGMP to 5'-AMP and 5'-GMP, respectively, thus terminating signal transduction. The cAMP-specific PDE4 isoforms may be particularly important in certain respiratory and neurological diseases. CP 80,633 is a selective...
Keywords: | 5-[3-[(1S,2S,4R)-bicyclo[2.2.1]hept-2-yloxy]-methoxyphenyl]tetrahydro-2-(1H)-pyrimidinone |
Application: | PDE4 inhibitor |
CAS | 135637-46-6 |
MW: | 316.4 D |
From 38.00€
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Item number: Cay13182-1
SU 5402 is an inhibitor of the tyrosine kinase domains of VEGFR2, FGFR1, and PDGFRbeta (IC50s = 0.02, 0.03, and 0.51 µM, respectively). It is much less effective against other receptor tyrosine kinases. SU 5402 is commonly used to evaluate the role of FGFR1 in cellular functions.Formal Name:...
Keywords: | 2-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid |
Application: | FGFR1 /?VEGFR2 inhibitor |
CAS | 215543-92-3 |
MW: | 296.3 D |
From 32.00€
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Item number: Cay13187-1
Most tissues have an endogenous pool of progenitor cells to draw from upon injury. The adult heart, however, contains a limited number of undifferentiated cells and techniques to replicate these cells from other pluripotent tissues have thus far been nonselective and inefficient. Cardiogenol C is a diaminopyrimidine...
Keywords: | 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-ethanol |
Application: | Differentiation of MHC-positive cardiomyocytes |
CAS | 671225-39-1 |
MW: | 296.8 D |
From 43.00€
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