5 products were found matching "Cay13179-%25"!

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CBHA
CBHA

Item number: Cay13172-25

Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. Importantly, HDAC inhibitors induce apoptosis in some cancer cells and show promise in the treatment of certain forms of cancer. CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 0.01 and...
Keywords: Histone Deacetylase Inhibitor II, m-Carboxycinnamic Acid bis-Hydroxamide,...
Application: HDAC inhibitor
CAS 174664-65-4
MW: 222.2 D
From 110.00€ *
Review
M 344
M 344

Item number: Cay13174-25

M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1 (IC50s = 88 and 249 nM, respectively). M 344 enhances the sensitivity of human squamous carcinoma cells to radiation...
Keywords: D237, Histone Deacetylase Inhibitor III, MS 344, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide
Application: HDAC inhibitor
CAS 251456-60-7
MW: 307.4 D
From 88.00€ *
Review
Imatinib (mesylate)
Imatinib (mesylate)

Item number: Cay13139-25

Imatinib is an inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit. It inhibits ligand-stimulated autophosphorylation of PDGFR and c-Kit (IC50s = ~0.3 and ~0.1 µM, respectively). Imatinib inhibits the proliferation of Bcr-Abl-dependent R10(-) cells (IC50s = ~35-40 nM) and HMC-1 cells...
Keywords: CGP57148B, STI-571,...
Application: Tyrosine kinase inhibitor
CAS 220127-57-1
MW: 589.7 D
From 40.00€ *
Review
Emodin
Emodin

Item number: Cay13109-25

Emodin is a naturally-occurring anthraquinone found in a variety of plants used in traditional Chinese medicine. Purified emodin has diverse effects, including the suppression of inflammation, dyslipidemia, and cancer. At a molecular level, emodin directly and selectively inhibits casein kinase II (IC50 = 0.89 µM)....
Keywords: Archin, Frangulic Acid, NSC 408120, NSC 622947, Schuttgelb, 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione
Application: CK2 inhibitor
CAS 518-82-1
MW: 270.2 D
From 40.00€ *
Review
XMD8-92
XMD8-92

Item number: Cay19173-25

XMD8-92 is an ERK5 inhibitor (Kd = 80 nM) that less potently inhibits DCAMKL2, TNK1, and Plk4 (Kds = 190, 890, and 600 nM, respectively) in a panel of 402 kinases. It blocks ERK5 autophosphorylation, ERK5-mediated phosphorylation of promyelocytic leukemia protein (PML), and PML-dependent activation of p21. XMD8-92...
Keywords: 2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Application: ERK5 inhibitor
CAS 1234480-50-2
MW: 474.6 D
From 43.00€ *
Review