- Search results for Cay13175-%25
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6 products were found matching "Cay13175-%25"!
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Item number: Cay13172-25
Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. Importantly, HDAC inhibitors induce apoptosis in some cancer cells and show promise in the treatment of certain forms of cancer. CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 0.01 and...
Keywords: | Histone Deacetylase Inhibitor II, m-Carboxycinnamic Acid bis-Hydroxamide,... |
Application: | HDAC inhibitor |
CAS | 174664-65-4 |
MW: | 222.2 D |
From 110.00€
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Item number: Cay13174-25
M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1 (IC50s = 88 and 249 nM, respectively). M 344 enhances the sensitivity of human squamous carcinoma cells to radiation...
Keywords: | D237, Histone Deacetylase Inhibitor III, MS 344, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide |
Application: | HDAC inhibitor |
CAS | 251456-60-7 |
MW: | 307.4 D |
From 88.00€
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Item number: Cay13571-25
The metabolism of F series prostaglandins (PGs), including PGF1alpha and PGF2alpha, commonly begins with the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs. The removal of four carbons at the alpha-terminus and oxidation of the...
Keywords: | 9alpha,11alpha-dihydroxy-15-oxo-2,3,4,5-tetranor prostanoic acid |
Application: | Bioactive lipid assays |
CAS | 24379-94-0 |
MW: | 300.4 D |
From 131.00€
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Item number: Cay13871-25
TAK-242 is an antagonist of toll-like receptor 4 (TLR4) with an IC50 value of 0.68 µM in a secreted alkaline phosphatase (SEAP) assay. It selectively binds to TLR4 over TLR1-3 and TLR5-10 when used at a concentration of 100 nM. TAK-242 (1 µM) prevents the interaction of TLR4 with its adaptor proteins TIRAP or TRAM...
Keywords: | Resatorvid, 6R-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid, ethyl ester |
Application: | TLR4 adaptor binding inhibitor |
CAS | 243984-11-4 |
MW: | 361.8 D |
From 98.00€
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Item number: Cay13271-25
ZLJ-6 is a dual inhibitor of COX and 5-lipoxygenase (5-LO) (IC50 = 0.73, 0.31, and 0.99 µM for COX-1, COX-2, and 5-LO, respectively, in whole blood). It reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers,...
Keywords: | (5Z)-2-amino-1,5-dihydro-1-methyl-5-[[4-(methylsulfonyl)phenyl]methylene]-4H-imidazol-4-one, monomethanesulfonate |
Application: | COX inhibitor, 5-LO inhibitor |
CAS | 1051931-39-5 |
MW: | 375.4 D |
From 53.00€
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Item number: Cay13371-25
CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 3.3 µM). It is selective for SPHK1 over SPHK2 at 10 µM and PKC at concentrations less than 100 µM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 µM.Formal Name:...
Keywords: | SKI 5C, SPHK1 Inhibitor 5C, (4S)-2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl... |
Application: | SPHK 1 inhibitor |
CAS | 120005-55-2 |
MW: | 435.6 D |
From 38.00€
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