6 products were found matching "Cay13175-%25"!

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CBHA
CBHA

Item number: Cay13172-25

Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. Importantly, HDAC inhibitors induce apoptosis in some cancer cells and show promise in the treatment of certain forms of cancer. CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 0.01 and...
Keywords: Histone Deacetylase Inhibitor II, m-Carboxycinnamic Acid bis-Hydroxamide,...
Application: HDAC inhibitor
CAS 174664-65-4
MW: 222.2 D
From 110.00€ *
Review
M 344
M 344

Item number: Cay13174-25

M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1 (IC50s = 88 and 249 nM, respectively). M 344 enhances the sensitivity of human squamous carcinoma cells to radiation...
Keywords: D237, Histone Deacetylase Inhibitor III, MS 344, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide
Application: HDAC inhibitor
CAS 251456-60-7
MW: 307.4 D
From 88.00€ *
Review
13,14-dihydro-15-keto-tetranor Prostaglandin F1alpha
13,14-dihydro-15-keto-tetranor Prostaglandin F1alpha

Item number: Cay13571-25

The metabolism of F series prostaglandins (PGs), including PGF1alpha and PGF2alpha, commonly begins with the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs. The removal of four carbons at the alpha-terminus and oxidation of the...
Keywords: 9alpha,11alpha-dihydroxy-15-oxo-2,3,4,5-tetranor prostanoic acid
Application: Bioactive lipid assays
CAS 24379-94-0
MW: 300.4 D
From 131.00€ *
Review
TAK-242
TAK-242

Item number: Cay13871-25

TAK-242 is an antagonist of toll-like receptor 4 (TLR4) with an IC50 value of 0.68 µM in a secreted alkaline phosphatase (SEAP) assay. It selectively binds to TLR4 over TLR1-3 and TLR5-10 when used at a concentration of 100 nM. TAK-242 (1 µM) prevents the interaction of TLR4 with its adaptor proteins TIRAP or TRAM...
Keywords: Resatorvid, 6R-[[(2-chloro-4-fluorophenyl)amino]sulfonyl]-1-cyclohexene-1-carboxylic acid, ethyl ester
Application: TLR4 adaptor binding inhibitor
CAS 243984-11-4
MW: 361.8 D
From 98.00€ *
Review
ZLJ-6
ZLJ-6

Item number: Cay13271-25

ZLJ-6 is a dual inhibitor of COX and 5-lipoxygenase (5-LO) (IC50 = 0.73, 0.31, and 0.99 µM for COX-1, COX-2, and 5-LO, respectively, in whole blood). It reduces carrageenin-induced paw edema (inflammation) in rats and acetic acid-induced abdominal constriction (pain) in mice without causing gastrointestinal ulcers,...
Keywords: (5Z)-2-amino-1,5-dihydro-1-methyl-5-[[4-(methylsulfonyl)phenyl]methylene]-4H-imidazol-4-one, monomethanesulfonate
Application: COX inhibitor, 5-LO inhibitor
CAS 1051931-39-5
MW: 375.4 D
From 53.00€ *
Review
CAY10621
CAY10621

Item number: Cay13371-25

CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 3.3 µM). It is selective for SPHK1 over SPHK2 at 10 µM and PKC at concentrations less than 100 µM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 µM.Formal Name:...
Keywords: SKI 5C, SPHK1 Inhibitor 5C, (4S)-2,2-dimethyl-4-(1-oxo-2-hexadecyn-1-yl)-3-oxazolidinecarboxylic acid, 1,1-dimethylethyl...
Application: SPHK 1 inhibitor
CAS 120005-55-2
MW: 435.6 D
From 38.00€ *
Review