- Search results for Cay13175
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10 products were found matching "Cay13175"!
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Item number: Cay13175-5
Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) amide is an FTS derivative with an amide added to the carboxyl group. FTS amide inhibits the growth of PANC-1 and U87 tumor cells with IC50 values of 20 and 10 µM,...
Keywords: | FTS Amide, Salirasib Amide, 2-[[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]thio]-benzamide |
Application: | Ras signaling inhibitor |
CAS | 1092521-74-8 |
MW: | 357.6 D |
From 26.00€
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Item number: Cay13317-5
Cyclin-dependent kinases (CDKs) play a key role in regulating cell division by phosphorylating distinct substrates in different phases of the cell cycle. Cell cycle deregulation in many cancers often results from altered CDK activity. Thus, CDKs are potential pharmacological targets for anticancer agents. NU 6102 is...
Keywords: | 4-[[6-(cyclohexylmethoxy)-9H-purin-2-yl]amino]-benzenesulfonamide |
Application: | CDK1 and CDK2 Inhibitor |
CAS | 444722-95-6 |
MW: | 402.5 D |
From 73.00€
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Item number: Cay13177-5
BYK 191023 is an L-arginine competitive and selective inhibitor of inducible nitric oxide synthase (iNOS) with IC50 values of 0.086, 17, and 162 µM for human recombinant iNOS, nNOS, and eNOS, respectively. It also inhibits murine recombinant iNOS (IC50 = 95 nM). BYK 191023 inhibits iNOS-induced nitrite generation in...
Keywords: | 2-[2-(4-methoxy-2-pyridinyl)ethyl]-3H-imidazo[4,5-b]pyridine, dihydrochloride |
Application: | iNOS inhibitor |
CAS | 1216722-25-6 |
MW: | 327.2 D |
From 125.00€
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Item number: Cay13172-5
Histone deacetylase (HDAC) inhibitors hyperacetylate histones and increase transcriptional activity in selected genes. Importantly, HDAC inhibitors induce apoptosis in some cancer cells and show promise in the treatment of certain forms of cancer. CBHA is a potent HDAC inhibitor, exhibiting ID50 values of 0.01 and...
Keywords: | Histone Deacetylase Inhibitor II, m-Carboxycinnamic Acid bis-Hydroxamide,... |
Application: | HDAC inhibitor |
CAS | 174664-65-4 |
MW: | 222.2 D |
From 110.00€
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Item number: Cay13178-5
The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases involved in gene regulation that is relevant to, e.g., longevity, cancer, gene regulation, energy homeostasis, and apoptosis. Salermide is an inhibitor of SIRT1 and SIRT2, causing tumor-specific apoptotic cell death. In MOLT4 leukemia cells,...
Keywords: | N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide |
Application: | SIRT inhibitor |
CAS | 1105698-15-4 |
MW: | 394.5 D |
From 68.00€
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Item number: Cay13174-5
M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1 (IC50s = 88 and 249 nM, respectively). M 344 enhances the sensitivity of human squamous carcinoma cells to radiation...
Keywords: | D237, Histone Deacetylase Inhibitor III, MS 344, 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide |
Application: | HDAC inhibitor |
CAS | 251456-60-7 |
MW: | 307.4 D |
From 88.00€
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Item number: Cay13179-5
Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid as products. There are three broad classes of PLA2, secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2), that...
Keywords: | 1,1,1,2,2-pentafluoro-7-phenyl-3-heptanone |
Application: | iPLA2 inhibitor |
CAS | 1071000-98-0 |
MW: | 280.2 D |
From 49.00€
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Item number: Cay13173-5
Redox-sensitive cysteine residues in proteins may function as sensors of reactive oxygen species (ROS) and also serve as molecular switches, activating or deactivating proteins, following a change in oxidation state. Modification of protein function through the reversible oxidation of cysteine is emerging as a...
Keywords: | Click Tag(TM) DAz-1, N-(3-azidopropyl)-3,5-dioxocyclohexane carboxamide |
Application: | Sulfenic acid detection |
CAS | 1112977-84-0 |
MW: | 238.2 D |
From 176.00€
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Item number: Cay13176-5
Oxamflatin is a potent inhibitor of histone deacetylases (IC50 = 15.7 nM). It has been shown to alter the expression of several genes whose products are involved in cell morphology, motility, apoptosis, and cell cycle control, reducing the proliferation of cancer cells.Formal Name:...
Keywords: | Metacept 3, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-2E-penten-4-ynamide |
Application: | HDAC inhibitor |
CAS | 151720-43-3 |
MW: | 342.4 D |
From 104.00€
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Item number: Cay13197-5
gamma-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Abeta), a 39- to 42-amino acid peptide which forms the amyloid plaques...
Keywords: | GSI-IX, N-[2S-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-glycine, 1,1-dimethylethyl ester |
Application: | gamma-secretase inhibitor |
CAS | 208255-80-5 |
MW: | 432.5 D |
From 75.00€
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