7 products were found matching "Cay13145"!

Mammalian sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in cell cycle progression and tumorigenesis. AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 µM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. It rescues...

Indirubin-3'-oxime is a potent inhibitor of glycogen synthase kinase 3beta (GSK3beta, IC50 = 22 nM). As GSK3beta phosphorylates tau protein, indirubin-3'-oxime prevents tau phosphorylation both in vitro and in vivo at Alzheimer's disease-relevant sites. It also inhibits cyclin-dependent kinases (CDKs) at higher...

Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-alkyl salicyclic acids having varying degrees of unsaturation in the 15-carbon alkyl chain. These compounds are associated with anti-inflammatory, anti-tumor, molluscicidal, and...

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase. Chelerythrine also inhibits Bcl-xL function (IC50 = 1.5 µM) by displacing Bax binding, inducing...

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with...

CAY10587 is a selective FFAR1 (GPR40) agonist (EC50 = 32 nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41). At 100 nM, CAY10587 increases glucose-stimulated insulin secretion in the rat insulin-secreting cell line INS-1E.Formal Name:...

PA-824 is an anti-tuberculosis (anti-TB) agent that is activated intracellularly via deazaflavin-dependent nitroreductase (Ddn) metabolism into a desnitro metabolite that kills M. tuberculosis by releasing reactive nitrogen species (RNS), including nitric oxide. It is active against replicating and non-replicating...