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Item number: Cay13139-25

Imatinib is an inhibitor of the receptor tyrosine kinases c-Abl, Bcr-Abl, PDGFR, and c-Kit. It inhibits ligand-stimulated autophosphorylation of PDGFR and c-Kit (IC50s = ~0.3 and ~0.1 µM, respectively). Imatinib inhibits the proliferation of Bcr-Abl-dependent R10(-) cells (IC50s = ~35-40 nM) and HMC-1 cells...

Keywords:	CGP57148B, STI-571,...
Application:	Tyrosine kinase inhibitor
CAS	220127-57-1
MW:	589.7 D

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