7 products were found matching "Cay13083-%25"!

DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230...

Darunavir is an HIV-1 protease inhibitor. It is active against HIV-1LAI in MT-2 cells (IC50 = 3 nM) with a cytotoxic concentration (CC50) of 74.4 µM. Darunavir is also active against wild-type and multidrug-resistant clinical isolates of HIV-1 in phytohemagglutinin-activated peripheral blood mononuclear cells...

[3,2-c]Furazan-5alpha-androstan-17beta-ol is a demethylated analog of the anabolic steroid stanozolol that features a furazan ring in place of the pyrazole group. [3,2-c]Furazan-5alpha-androstan-17beta-ol is considered a designer anabolic steroid and is regulated in the United States. The physiological and...

Prostaglandin F2alpha-1-glyceryl ester-d5 (PGF2alpha-1-glyceryl ester-d5) is intended for use as an internal standard for the quantification of PGF2alpha-1-glyceryl ester by GC- or LC-MS. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid...

Pachymic acid is a triterpenoid that has been found in P. cocos and has diverse biological activities. It inhibits hexokinase 2 (HK2, IC50 = 5.01 µM), as well as reduces glucose uptake and lactate production in SK-BR-3 breast cancer cells. Pachymic acid inhibits IL-1beta-induced cytosolic phospholipase A2 (cPLA2)...

Vortioxetine is a multimodal serotonergic agent that acts as a serotonin (5-HT, Cay-14332) reuptake inhibitor (Ki = 1.6 nM) and binds to the 5-HT1A, 5-HT1B, 5-HT3A, and 5-HT7 receptors (Kis = 15, 33, 3.7, and 19 nM, respectively). It also binds to the beta1-adrenergic receptor (Ki = 46 nM). It acts as an antagonist...

The rapid, selective, and sensitive sensing of thiols is important in diverse areas of research. This Thiofluor 623 responds upon exposure to thiols with an increase in fluorescence intensity of up to 120-fold. The response is selective for thiols and occurs in aqueous media. In the absence of thiols, the probe is...