11 products were found matching "Cay13082-%25"!

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STF-62247
STF-62247

Item number: Cay13084-25

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247...
Keywords: N-(3-methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
Application: Autophagy inducer
CAS 315702-99-9
MW: 267.3 D
From 81.00€ *
Review
Tenovin-6 (hydrochloride)
Tenovin-6 (hydrochloride)

Item number: Cay13086-25

The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 µM, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces...
Keywords: N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide
Application: SIRT inhibitor
CAS 1011301-29-3
MW: 491.1 D
From 216.00€ *
Review
Fucoxanthin
Fucoxanthin

Item number: Cay13068-25

Fucoxanthin is a carotenoid that occurs naturally in certain algae. It significantly reduces abdominal white adipose tissue (WAT) in mice and rats when included in their diet. Fucoxanthin increases the amount of mitochondrial uncoupling protein 1 (UCP1), a fatty acid-stimulated protein involved in respiration and...
Keywords: 6'R,7'-didehydro-5R,6-epoxy-4',5',6S,7-tetrahydro-3S,3'S,5'R-trihydroxy-beta,beta-caroten-8(5H)-one
Application: Metabolic studies
CAS 3351-86-8
MW: 658.9 D
From 115.00€ *
Review
MPI-0441138
MPI-0441138

Item number: Cay13098-25

MPI-0441138 is a potent inducer of apoptosis and growth inhibition (EC50 = 2 nM for both processes, based on caspase-3 activation and total cellular ATP, respectively) in T47D and HCT116 cells. MPI-0441138 has excellent blood brain barrier penetration and is effective in mouse xenograft cancer models.Formal Name:...
Keywords: EP128265, 2-chloro-N-(4-methoxyphenyl)-N-methyl-4-quinazolinamine
Application: Apoptosis inducer
CAS 827030-33-1
MW: 299.8 D
From 50.00€ *
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JWH 193
JWH 193

Item number: Cay13980-25

JWH 193 is a synthetic cannabinoid (CB) which binds the central CB1 receptor with high affinity (Ki = 6 nM). This aminoalkylindole shares structural features with the antinociceptive CB1 agonists pravadoline (Cay-10006973) and WIN 55,212-2. The physiological and toxicological properties of this compound have not...
Keywords: (4-methyl-1-naphthalenyl)[1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-methanone
Application: Analytical reference standard, Synthetic cannabinoid
CAS 133438-58-1
MW: 398.5 D
From 276.00€ *
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Misoprostol
Misoprostol

Item number: Cay13820-25

Misoprostol is an analog of prostaglandin E1 (PGE1, Cay-13010) and an agonist of the PGE2 receptor subtypes EP2 and EP3. It binds to EP1, EP2, EP3-III, and EP4 receptors (Kis = 35.675, 10.249, 0.319, 5.499 µM, respectively) and is selective for EP receptors over DP, FP, IP, and TP receptors (Kis = >100 µM for all)....
Keywords: SC 29333, 9-oxo-11alpha,16-dihydroxy-16-methyl-prost-13E-en-1-oic acid, methyl ester
Application: EP receptor agonist
CAS 59122-46-2
MW: 382.5 D
From 27.00€ *
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Reboxetine (mesylate)
Reboxetine (mesylate)

Item number: Cay15038-25

Reboxetine is an antidepressant compound that selectively inhibits norepinephrine uptake (IC50s = 8.2 and 1,070 nM for norepinephrine and serotonin transporters, respectively). It displays greater than 1,000-fold affinity for binding rat norepinephrine receptors compared to serotonin, histamine, acetylcholine, or...
Keywords: Davedax, Edronax, FCE 20124, PNU 155950E, (2R)-rel-2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-morpholine, methanesulfonate
Application: Norepinephrine uptake inhibitor, Noradrenalin transporter inhibitor
CAS 98769-84-7
MW: 409.5 D
From 84.00€ *
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(E/Z)-4-hydroxy Tamoxifen
(E/Z)-4-hydroxy Tamoxifen

Item number: Cay17308-25

(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258). It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the...
Keywords: 4-hydroxy Tamoxifen, 4-OHT, Afimoxifene, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
Application: Active tamoxifen metabolite, estrogen receptor agonist/antagonist
CAS 68392-35-8
MW: 387.5 D
From 43.00€ *
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VX-702
VX-702

Item number: Cay13108-25

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38alpha and p38beta (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1beta, and TNF-alpha production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml,...
Keywords: 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide
Application: p38 MAP kinase inhibitor
CAS 745833-23-2
MW: 404.3 D
From 34.00€ *
Review
PF-4989216
PF-4989216

Item number: Cay19308-25

PF-4989216 is an orally bioavailable broad-spectrum PI3K inhibitor (IC50s = 2, 142, 65, 1, and 110 nM for p110alpha, p110beta, p110gamma, p110delta, and VPS34, respectively). It inhibits the cell viability of small-cell lung cancer (SCLC) cells with a mutation in PIK3CA, blocking PI3K downstream signaling and...
Keywords: 4-(4-cyano-2-fluorophenyl)-2-(4-morpholinyl)-5-(1H-1,2,4-triazol-5-yl)-3-thiophenecarbonitrile
Application: PI3K inhibitor
CAS 1276553-09-3
MW: 380.4 D
From 60.00€ *
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NU 7026
NU 7026

Item number: Cay13308-25

DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230...
Keywords: DNA-PK Inhibitor II, LY293646, 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
Application: DNA-PK inhibitor
CAS 154447-35-5
MW: 281.3 D
From 109.00€ *
Review