- Search results for Cay13082-%25
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11 products were found matching "Cay13082-%25"!
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Item number: Cay13084-25
STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247...
Keywords: | N-(3-methylphenyl)-4-(4-pyridinyl)-2-thiazolamine |
Application: | Autophagy inducer |
CAS | 315702-99-9 |
MW: | 267.3 D |
From 81.00€
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Item number: Cay13086-25
The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 µM, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces...
Keywords: | N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-benzamide |
Application: | SIRT inhibitor |
CAS | 1011301-29-3 |
MW: | 491.1 D |
From 216.00€
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Item number: Cay13068-25
Fucoxanthin is a carotenoid that occurs naturally in certain algae. It significantly reduces abdominal white adipose tissue (WAT) in mice and rats when included in their diet. Fucoxanthin increases the amount of mitochondrial uncoupling protein 1 (UCP1), a fatty acid-stimulated protein involved in respiration and...
Keywords: | 6'R,7'-didehydro-5R,6-epoxy-4',5',6S,7-tetrahydro-3S,3'S,5'R-trihydroxy-beta,beta-caroten-8(5H)-one |
Application: | Metabolic studies |
CAS | 3351-86-8 |
MW: | 658.9 D |
From 115.00€
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Item number: Cay13098-25
MPI-0441138 is a potent inducer of apoptosis and growth inhibition (EC50 = 2 nM for both processes, based on caspase-3 activation and total cellular ATP, respectively) in T47D and HCT116 cells. MPI-0441138 has excellent blood brain barrier penetration and is effective in mouse xenograft cancer models.Formal Name:...
Keywords: | EP128265, 2-chloro-N-(4-methoxyphenyl)-N-methyl-4-quinazolinamine |
Application: | Apoptosis inducer |
CAS | 827030-33-1 |
MW: | 299.8 D |
From 50.00€
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Item number: Cay13980-25
JWH 193 is a synthetic cannabinoid (CB) which binds the central CB1 receptor with high affinity (Ki = 6 nM). This aminoalkylindole shares structural features with the antinociceptive CB1 agonists pravadoline (Cay-10006973) and WIN 55,212-2. The physiological and toxicological properties of this compound have not...
Keywords: | (4-methyl-1-naphthalenyl)[1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-methanone |
Application: | Analytical reference standard, Synthetic cannabinoid |
CAS | 133438-58-1 |
MW: | 398.5 D |
From 276.00€
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Item number: Cay13820-25
Misoprostol is an analog of prostaglandin E1 (PGE1, Cay-13010) and an agonist of the PGE2 receptor subtypes EP2 and EP3. It binds to EP1, EP2, EP3-III, and EP4 receptors (Kis = 35.675, 10.249, 0.319, 5.499 µM, respectively) and is selective for EP receptors over DP, FP, IP, and TP receptors (Kis = >100 µM for all)....
Keywords: | SC 29333, 9-oxo-11alpha,16-dihydroxy-16-methyl-prost-13E-en-1-oic acid, methyl ester |
Application: | EP receptor agonist |
CAS | 59122-46-2 |
MW: | 382.5 D |
From 27.00€
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Item number: Cay15038-25
Reboxetine is an antidepressant compound that selectively inhibits norepinephrine uptake (IC50s = 8.2 and 1,070 nM for norepinephrine and serotonin transporters, respectively). It displays greater than 1,000-fold affinity for binding rat norepinephrine receptors compared to serotonin, histamine, acetylcholine, or...
Keywords: | Davedax, Edronax, FCE 20124, PNU 155950E, (2R)-rel-2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-morpholine, methanesulfonate |
Application: | Norepinephrine uptake inhibitor, Noradrenalin transporter inhibitor |
CAS | 98769-84-7 |
MW: | 409.5 D |
From 84.00€
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Item number: Cay17308-25
(E/Z)-4-hydroxy Tamoxifen is an active metabolite of tamoxifen (Cay-13258). It is formed from tamoxifen by the cytochrome P450 (CYP) isoform CYP2D6. (E/Z)-4-hydroxy Tamoxifen is cytotoxic to MCF-7 and MDA-MB-231 breast cancer cells (IC50s = 27 and 18 µM, respectively). It also stimulates LC3 lipidation and the...
Keywords: | 4-hydroxy Tamoxifen, 4-OHT, Afimoxifene, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol |
Application: | Active tamoxifen metabolite, estrogen receptor agonist/antagonist |
CAS | 68392-35-8 |
MW: | 387.5 D |
From 43.00€
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Item number: Cay13108-25
VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38alpha and p38beta (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1beta, and TNF-alpha production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml,...
Keywords: | 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide |
Application: | p38 MAP kinase inhibitor |
CAS | 745833-23-2 |
MW: | 404.3 D |
From 34.00€
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Item number: Cay19308-25
PF-4989216 is an orally bioavailable broad-spectrum PI3K inhibitor (IC50s = 2, 142, 65, 1, and 110 nM for p110alpha, p110beta, p110gamma, p110delta, and VPS34, respectively). It inhibits the cell viability of small-cell lung cancer (SCLC) cells with a mutation in PIK3CA, blocking PI3K downstream signaling and...
Keywords: | 4-(4-cyano-2-fluorophenyl)-2-(4-morpholinyl)-5-(1H-1,2,4-triazol-5-yl)-3-thiophenecarbonitrile |
Application: | PI3K inhibitor |
CAS | 1276553-09-3 |
MW: | 380.4 D |
From 60.00€
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Item number: Cay13308-25
DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230...
Keywords: | DNA-PK Inhibitor II, LY293646, 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one |
Application: | DNA-PK inhibitor |
CAS | 154447-35-5 |
MW: | 281.3 D |
From 109.00€
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