13 products were found matching "Cay13055"!

Furin is a proprotein convertase, converting precursor proteins to functional proteins within the Golgi/trans-Golgi secretory pathway. Naphthofluorescein is a cell-permeable inhibitor of furin (IC50 = 12 µM). It inhibits furin-mediated cleavage of the pro-form of membrane type-1 matrix metalloproteinase (MT1-MMP),...

1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become 'analog sensitive' (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28...

The cytochalasins are cell-permeable fungal metabolites that inhibit actin polymerization. This interferes with such diverse processes as cell movement, growth, phagocytosis, degranulation, and secretion. Cytochalasin D is a cell-permeable inhibitor that binds actin filaments, but not actin monomers, to inhibit...

Bisindolylmaleimide V (BIM V) is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 µM. While effectively inactive as a PKC inhibitor, BIM V blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM.Formal Name:...

L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR, Kd = ~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in...

D 4476 is a cell-permeant inhibitor of casein kinase 1 (CK1, IC50 = 200 nM from S. pombe, 300 nM for CK1delta). It is a less effective inhibitor of PKD1 (IC50 = 9.1 µM) and p38alpha MAPK (IC50 = 5.8 µM), and only weakly affects the activities of a panel of kinases tested. D 4476 blocks CK1-mediated phosphorylation...

4-Pyridylamide oxime is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: N-hydroxy-4-pyridinecarboximidamide. CAS Number: 1594-57-6. Synonyms: NSC 43969. Molecular Formula: C6H7N3O. Formula Weight: 137.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid....

Prostaglandin E1 (PGE1) is not a major naturally occurring PG, but is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction, and in neonatal cardiology. COX metabolism of the unusual fatty acid 10,13,16-docosatrienoic acid yields 1a,1b-dihomo...

3-methyl Benzamideoxime is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: N-hydroxy-3-methyl-benzenecarboximidamide. CAS Number: 40067-82-1. Synonyms: m-Tolylamideoxime. Molecular Formula: C8H10N2O. Formula Weight: 150.2. Purity: >98%. Formulation: (Request formulation change), A...

ethyl-2-amino-4-methyl-Thiazole-5-carboxylate is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: 2-amino-4-methyl-5-thiazolecarboxylic acid, ethyl ester. CAS Number: 7210-76-6. Synonyms: EMTC, NSC 400231. Molecular Formula: C7H10N2O2S. Formula Weight: 186.2. Purity: >98%. Formulation:...

4-Pyridylthioamide is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: 4-pyridinecarbothioamide. CAS Number: 2196-13-6. Synonyms: NSC 1607, Thioisonicotinamide. Molecular Formula: C6H6N2S. Formula Weight: 138.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid....

Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the maintenance of normal bone mass via signaling through the CB2 receptor. N-Oleoyl-L-serine is an...