9 products were found matching "Cay13042-%25"!

The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. PD 0325901 is a potent MEK inhibitor that suppresses phosphorylation of ERK in mouse colon 26 tumors with an IC50 value of 0.33 nM. Suppression of ERK activation...

Biotin-azide is a form of biotin with a terminal azide group. It is used to add biotin to other molecules that bear either an alkyne group, through click chemistry, or a phosphine group, using Staudinger ligation. Biotin-azide has been commonly used to biotin-tag alkynylated lipids, particularly those associated...

2-Pyridylthioamide is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: 2-pyridinecarbothioamide. CAS Number: 5346-38-3. Synonyms: NSC 1606, Picolinic Acid Thioamide. Molecular Formula: C6H6N2S. Formula Weight: 138.2. Purity: >98%. Formulation: (Request formulation change), A crystalline...

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM). It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice. STF-62247...

N-pentadecanoyl-L-Homoserine lactone is an N-acyl homoserine lactone produced by Y. pseudotuberculosis and a bacterial quorum-sensing signaling molecule. It activates the LasR quorum sensing receptor of bacteria in a reporter assay. N-pentadecanoyl-L-Homoserine lactone induces GFP production in a P. putida F117...

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production,...

As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions. Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in...

PF-543 is a potent inhibitor of sphingosine kinase 1 (SPHK1, IC50 = 2 nM) that inhibits sphingosine-1-phosphate (S1P) binding to human recombinant SPHK1 (Ki = 3.6 nM). It is selective for SPHK1 over SPHK2 (IC50 = 356 nM) as well as a panel of protein and lipid kinases and S1P receptors at a concentration of 10 µM....

Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. HA-155 is a boronic acid-based compound that inhibits autotaxin (IC50 = 5.7 nM) by selectively binding to its catalytic threonine. It has been shown to...