11 products were found matching "Cay12055"!

BW 246C (Cay-12055) is the less active C-8 diastereomer of the DP receptor agonist BW 245C. The activity of BW 245C is 70-fold greater than that of BW 246C.Formal Name: (4R)-rel-(3-[(3R,S)-3-cyclohexyl-3-hydroxypropyl]-2,5-dioxo)-4-imidazolidineheptanoic acid. CAS Number: 65705-83-1. Synonyms: 8-epi BW 245C....

Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH). Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells....

Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of this...

Prostaglandin D1 (PGD1) is the 1-series analog of PGD2 (Cay-12010). It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2.Formal Name: 9alpha,15S-dihydroxy-11-oxo-prost-13E-en-1-oic acid. CAS Number: 17968-82-0. Synonyms: PGD1. Molecular...

MAM2201 N-(5-chloropentyl) analog-d5 (Cay-12052) is intended for use as an internal standard for the quantification of MAM2201 N-(5-chloropentyl) analog (Cay-13103) by GC- or LC-MS. MAM2201 (Cay-9001219) is a synthetic cannabinoid (CB) that is closely related, structurally, to AM2201 (Cay-10707), a compound which...

Propylhexedrine is an alpha-adrenergic sympathomimetic amine that acts as a local vasoconstrictor. It is the active ingredient in some over-the-counter nasal decongestants but may be abused, typically by intravenous or oral delivery of the nasal decongestant. This product is intended for research and forensic...

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J1 is a potent inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50s = 18 and 56 µM, respectively as measured by mass...

BW 245C is a selective agonist for the DP1 receptor. The Ki of BW 245C for the inhibition of [3H]-PGD2 binding to isolated human platelet membranes is 0.9 nM. It has a reported IC50 of 2.5 nM for the inhibition of ADP-induced human platelet aggregation and an IC50 of 250 nM for the inhibition of rat platelet...

The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. GSK-J2 is a pyridine regio-isomer of GSK-J1 which poorly inhibits JMJD3 (IC50 > 100 µM), making it an appropriate negative control...

Neopterin is a pyrazino-pyrimidine compound derived from GTP that represents an intermediate product in the synthetic pathway of biopterin and is an essential cofactor in neurotransmitter synthesis. Neopterin is released from macrophages upon immune stimulation with interferon-gamma from activated T cells. It is...

The cysteinyl leukotrienes (cysLTs, LTC4, LTD4, and LTE4) contract airway and pulmonary vascular smooth muscle, increase vascular permeability, and stimulate mucus secretion, thereby playing a major role in asthma. LTC4, LTD4, and LTE4 mediate their actions via at least two receptors designated CysLT1 and CysLT2....