15 products were found matching "Cay12000"!

Prostaglandin D1 (PGD1) is the 1-series analog of PGD2 (Cay-12010). It is an inhibitor of ADP-induced platelet aggregation in humans with an IC50 value of 320 ng/ml, about 1/10 as potent as PGD2.Formal Name: 9alpha,15S-dihydroxy-11-oxo-prost-13E-en-1-oic acid. CAS Number: 17968-82-0. Synonyms: PGD1. Molecular...

Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of this...

Mild oxidation can convert the sulfhydryl group of cysteine residues on proteins to cysteine-sulfenic acid derivatives (Cys-SOH). Protein sulfenylation, then, is a post-translational modification that is relevant to redox signaling. DYn-2 is a chemoselective probe for detecting sulfenylated proteins in intact cells....

3,4-Methylenedioxy Pyrovalerone (3,4-MDPV, Cay-10684) is an analog of pyrovalerone (Cay-10817) that includes the 3,4-methylenedioxy moiety found on 3,4-methylenedioxymethamphetamine (Cay-13971), a DEA Schedule I controlled substance. 3,4-MDPV is commonly abused as a recreational drug. 3,4-MDPV metabolite 2 is...

Rottlerin was originally identified as an inhibitor of PKCdelta (IC50 = 3 µM), but can also inhibit CAM kinase III and a wide range of protein kinases, including PRAK and MAPKAP-K2 (IC50s = 1.9 and 5 µM, respectively). It can act as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling...

Buphedrone (Cay-11486) is a substituted cathinone, analogous to methcathinone, which has been identified in products that are sold as stimulants. 3-Methylbuphedron is a methylated analog of buphedrone. Its biological and toxicological properties have not been evaluated. This product is intended for forensic and...

UR-144 (Cay-11502) is a potent synthetic cannabinoid (CB) which preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM). UR-144 N-(5-bromopentyl) analog (Cay-12003) differs from UR-144 by having a bromine atom on the terminal carbon of the alkyl group. While similar...

Prostaglandin D1 (PGD1) alcohol is the synthetic analog of PGD1 with a primary alcohol in place of the C-1 carboxyl. There are no known reports of its biological activity. PGD1 is the theoretical D-series metabolite of dihomo-gamma-linolenic acid (DGLA), but to date it has not been isolated as a natural product. It...

Haloperidol is a typical antipsychotic and dopamine D2-like receptor antagonist (Kis = 0.6, 0.2, and 22 nM, for D2, D3, and D4 receptors, respectively). It also acts as an inverse agonist at dopamine D2 and D3 receptors (IC50s = 0.8 and 0.6 nM, respectively). Haloperidol also binds to alpha1- and alpha2- adrenergic...

Glimepiride is an inhibitor of sulfonylurea receptors (SURs) linked to the inwardly rectifying potassium channel (Kir6.2, IC50s = 3, 5.4, and 7.3 nM for SUR1/Kir6.2, SUR2A/Kir6.2, and SUR2B/Kir6.2, respectively, in Xenopus oocytes expressing the mouse receptor). It also induces intracellular insulin receptor (InsR)...

25-hydroxy Vitamin D2 is a metabolite of vitamin D2 (Cay-11791). It is formed from vitamin D2 by the cytochrome P450 (CYP) isoforms CYP2R1 and CYP27A1, which have 25-hydroxylase activity, and is bound to vitamin D binding protein (DBP) and albumin in the liver, then secreted into the bloodstream. 25-hydroxy Vitamin...

Bosutinib is an inhibitor of c-Src and Abl kinases (IC50s = 1.2 and 1 nM, respectively). It also inhibits the kinases EPHB2, TrkA, TrkB, and TXK (IC50s = 8.5, 22, 27, and 40 nM, respectively) among others. Bosutinib inhibits Src-dependent cell proliferation (IC50 = 100 nM) and reverses Src-transformed fibroblasts to...