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JMJD2A, human recombinant

ART NR.: Cay10336-25 (25 µg)
Cay10336-50 (50 µg)
Cay10336-100 (100 µg)

Hersteller: Cayman


Anwendungen: Demethylation assays

MW: 43 kD

Reinheit: >95%

Format: solution

Lagerung: -80°C

Versand: -20°C

UniProt ID: O75164 | Suche mit UniProt ID

KEGG ID: K06709 | Suche mit KEGG ID

Schlagworte: KDM4A, JHDM3A, EC=1.14.11.-, Lysine-specific demethylase 4A, Jumonji domain-containing protein 2A, JmjC domain-containing histone demethylation protein 3A


25 µg

113 €


50 µg

210 €


100 µg

412 €

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Bemerkungen: Recombinant N-terminal hexahistadine-tagged protein, expressed in E.coli, Mr 43,0 kDa. Methylation of lysine residues of core histones plays a critical role in the regulation of gene expression. Jumonji domain containing 2A (JMJD2A) is the first reported trimethyllysine-specific histone demethylase. It catalyzes the demethylation of tri- and di-methylated forms of histone H3 at lysine residues 9 and 36. Like other JmjC protein hydroxylase family members, JMJD2A is an alpha-ketoglutate-dependant Fe (II) oxygenase. JMJD2A's transcriptional function appears to depend on protein associations, as it is implicated in both transcriptional silencing and upregulation of the androgen receptor-dependent genes. Because of their implication in cancer cell growth, jumonji C domain-containing histone demethylases may be drug discovery targets for therapeutic intervention.
Image Art Cay10336-25 Cayman JMJD2A, human recombinant

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