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Cay10320-100
Enzyme kinetics Erklärungen der Abkürzungen ansehen.
Source: recombinant N-terminal hexahistidine-tagged SET7/9 amino acids 1-366, purified from E. coli. Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase. SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10. Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation. SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.

MW: 43 kD
Purity: >95%
Cayman
Icon Datasheet
100 µg

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137 €

Cay10320-50
Enzyme kinetics Erklärungen der Abkürzungen ansehen.
Source: recombinant N-terminal hexahistidine-tagged SET7/9 amino acids 1-366, purified from E. coli. Methylation of lysine can promote transcriptional activation or repression and is critical in regulating histone function. Lysine residues can be mono-, di-, or tri-methylated, and unlike most SET proteins, SET7/9 is exclusively a mono-methylase. SET7/9 methylates histone H3, tumor suppressor p53, and transcription factor TAF10. Recently, SET7/9 was shown to catalyze methylation of p53 in response to DNA damage thereby activating p53 for subsequent acetylation. SET7/9 is able to modulate p53 activity in a human cancer cell line, implying that it may play a significant role in human tumorigenesis.

MW: 43 kD
Purity: >95%
Cayman
Icon Datasheet
50 µg

Buy Bulk

72 €


 

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