- Search results for Cay10315-%25
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8 products were found matching "Cay10315-%25"!
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Item number: Cay10310-25
Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and...
Keywords: | PGA3, 9-oxo-15S-hydroxy-prosta-5Z,10,13E,17Z-tetraen-1-oic acid |
Application: | Bioactive lipid assays |
CAS | 36614-31-0 |
MW: | 332.4 D |
From 130.00€
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Item number: Cay10312-25
F2 isoprostanes (F2-iPs) are thought to arise from the free radical-mediated peroxidation of phospholipid-bound arachidonic acid. They are cleaved, presumably by an unidentified phospholipase A2, and are found in the circulation and the urine. 8,12-iso-iPF2alpha-VI-1,5-lactone is a racemic mixture of the lactone...
Keywords: | 6-((E)-2-((1R,2S,3R,5S)-3,5-dihydroxy-2-((Z)-oct-2-enyl)cyclopentyl)vinyl)tetrahydro-2H-pyran-2-one |
Application: | Bioactive lipid assays |
MW: | 336.5 D |
From 156.00€
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Item number: Cay14031-5
Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. It is a protein kinase C activator that displays a Ki value of 30 µM and an ED50 value of 27 µM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for...
Keywords: | (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1H-2... |
Application: | PKC activator |
CAS | 30220-46-3 |
MW: | 348.4 D |
From 46.00€
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Item number: Cay10011305-25
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific effects on sodium transport in the kidney.17(S)-HETE inhibits proximal tubule ATPase activity by as much as 70% at...
Keywords: | 17S-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid |
Application: | Bioactive lipid assays |
CAS | 183509-25-3 |
MW: | 320.5 D |
From 196.00€
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Item number: Cay10010345-25
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-nap... |
Application: | Inhibitor of HMG-CoA reductase |
CAS | 101314-97-0 |
MW: | 458.6 D |
From 48.00€
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Item number: Cay10010355-25
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki =...
Keywords: | Grapiprant, RQ-00000007,... |
Application: | EP4R antagonist |
CAS | 415903-37-6 |
MW: | 491.6 D |
From 43.00€
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Item number: Cay10011385-25
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bim/BOD is a group of three splice variants, BimEL, BimL and BimS, with apparent molecular masses of ~23, 16, and 13 kDa, respectively. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain...
Keywords: | Anti-BIM, Anti-BCL2L11, Anti-Bcl2-L-11, Anti-Bcl-2-like protein 11, Anti-Bcl2-interacting mediator of cell death |
Application: | WB, IHC |
Host: | Rabbit |
Species reactivity: | human |
From 205.00€
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Item number: Cay10010315-25
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
Keywords: | Tyrphostin 51, 2-amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile |
Application: | EGF receptor kinase inhibitor |
CAS | 122520-90-5 |
MW: | 268.2 D |
From 54.00€
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