- Search results for Cay10227-%25
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14 products were found matching "Cay10227-%25"!
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Item number: Cay13207-25
Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are...
Keywords: | N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide |
Application: | PLD2 inhibitor |
CAS | 1130067-34-3 |
MW: | 428.5 D |
From 68.00€
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Item number: Cay18207-25
The chemokine CCL2, also known as monocyte chemotactic protein-1 (MCP-1), stimulates leukocyte chemotaxis to sites of inflammation via signaling through the MCP-1 receptor, CCR2. RS 102895 is a spiropiperidine compound that acts as a CCR2 antagonist (IC50 = 0.36 µM). It inhibits the related CCR1 receptor with an...
Keywords: | 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one, monohydrochloride |
Application: | CCR2 antagonist |
CAS | 1173022-16-6 |
MW: | 426.9 D |
From 46.00€
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Item number: Cay15207-25
The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation. A-967079 is a potent, selective, and bioavailable inhibitor of the...
Keywords: | (1E,3E)-1-(4-fluorophenyl)-2-methyl-1-penten-3-one oxime |
Application: | TRPA1 inhibitor |
CAS | 1170613-55-4 |
MW: | 207.3 D |
From 88.00€
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Item number: Cay10007902-25
Sphingosine is an amino alcohol most commonly characterized by an 18-carbon unsaturated hydrocarbon chain sphingosine (d18:1) (Cay-10007907). However, the hydrocarbon chain length of sphingosine, and the related dihydrosphingosine, can vary from 12-26 carbons in mammalian tissues. Sphingosine (d17:1) is a...
Keywords: | D-erythro-Sphingosine C-17, 2S-amino-4E-heptadecene-1,3R-diol |
Application: | Standard |
CAS | 6918-48-5 |
MW: | 285.5 D |
From 43.00€
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Item number: Cay10007912-25
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This omega-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing...
Keywords: | 20-carboxy AA, 20-COOH-AA, 5Z,8Z,11Z,14Z-eicosatetraenedioic acid |
Application: | Bioactive lipid assays |
CAS | 79551-84-1 |
MW: | 334.5 D |
From 300.00€
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Item number: Cay10007662-25
L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs)....
Keywords: | L-erythro-Biopterin, NSC 339699, 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone |
Application: | NOS cofactor |
CAS | 22150-76-1 |
MW: | 237.2 D |
From 53.00€
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Item number: Cay10007412-25
Combrestatin A4 (CA4) is a potent inhibitor of tubulin polymerization and displays strong inhibitory activity on tumor cell growth. Combrestatin A4 was shown to inhibit tumor growth in several cell lines including IMR32 (neuroblastoma), Hs746T (gastric carcinoma), CFPAC-1 (pancreatic carcinoma), and MCF-7 (breast...
Keywords: | CA4, Combretastatin A4, CRC 87-09, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-phenol |
Application: | Tubulin polymerization inhibitor |
CAS | 117048-59-6 |
MW: | 316.4 D |
From 85.00€
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Item number: Cay10007132-25
(R)-(-)-2-Phenylglycinol is a synthetic intermediate useful for pharmaceutical synthesis.Formal Name: betaR-amino-benzeneethanol. CAS Number: 56613-80-0. Molecular Formula: C8H11NO. Formula Weight: 137.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 50 mg/ml, DMSO:...
Keywords: | betaR-amino-benzeneethanol |
Application: | Synthetic intermediate, pharmaceutical synthesis |
CAS | 56613-80-0 |
MW: | 137.2 D |
From 22.00€
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Item number: Cay10007012-25
12-oxo Stearic acid methyl ester is an esterified form of 12-oxo stearic acid. It has been found in esterified L. chinensis and L. decipiens pulp oils and serves as a measure of 12-oxo stearic acid content.Formal Name: 12-oxo-octadecanoic acid, methyl ester. CAS Number: 2380-27-0. Synonyms: Methyl 12-oxo...
Keywords: | Methyl 12-keto Stearate, Methyl 12-oxo Octadecanoate, Methyl 12-oxo Stearate, 12-oxo-octadecanoic acid, methyl ester |
CAS | 2380-27-0 |
MW: | 312.5 D |
From 88.00€
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Item number: Cay10007452-25
Vinclozolin M2 is an active metabolite of vinclozolin (Cay-23939). It is formed from vinclozolin by successive esterase activity and decarboxylation of vinclozolin in C. elegans and by decarboxylation in human liver microsomes. Vinclozolin M2 is an antagonist of the mineralocorticoid receptor (IC50 = 1,400 nM) and...
Keywords: | M2, N-(3,5-dichlorophenyl)-2-hydroxy-2-methyl-3-butenamide |
Application: | Dicarboximide fungicide, rat androgen receptor antagonist |
CAS | 83792-61-4 |
MW: | 260.1 D |
From 65.00€
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Lipid-based Drug Delivery Tools
Item number: Cay10172-25
1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A2 (PLA2) hydrolysis of phosphatidylcholine. It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and...
Keywords: | 16:0/0:0-PC, 1-Hexadecanoyl-sn-glycero-3-Phosphatidylcholine, 1-Hexadecanoyl-sn-glycero-3-Phosphocholine,... |
Application: | Bioactive lipid assays |
CAS | 17364-16-8 |
MW: | 495.6 D |
From 66.00€
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Item number: Cay10792-25
The enzyme Delta6 desaturase mediates the conversion of linoleic acid to gamma-linolenic acid (GLA), which can then be elongated to dihomo-gamma-linolenic acid (DGLA). DGLA can then be used as a substrate for Delta5 desaturase to produce arachidonic acid (AA), the fatty acid that is used to generate eicosanoids....
Keywords: | alpha,alpha-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile,... |
Application: | Delta6 desaturase inhibitor |
CAS | 218136-59-5 |
MW: | 423.6 D |
From 43.00€
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