C16 Ceramide is a sphingolipid. It incorporates into the mitochondrial outer membrane and forms channels that increase its permeability. C16 Ceramide levels are increased by PPMP or MAPP in isolated human neutrophils and are correlated with an increase in apoptosis. It accumulates in the lungs of patients with...

Resveratrol is a potent phenolic antioxidant found in natural sources that has antiproliferative activity. When the three phenolic hydroxyl groups of resveratrol are converted to methyl ethers, the inhibition of cell growth is enhanced. 3,4',5-Trismethoxybenzophenone is an analog of trismethoxy resveratrol. It...

CAY10441 is an antagonist of the IP receptor. It is selective for the IP receptor over the prostaglandin E2 (PGE2) receptor subtypes EP1, EP2, EP3, and EP4, the FP and TP receptors, and a panel of 30 other receptors and ion channels but does bind to the alpha2A-adrenergic and imidazoline I2 receptors. CAY10441...

DAUDA is an environment-sensitive fluorescent fatty acid analogue that alters its fluorescent emission spectra and intensities on entry into binding proteins. DAUDA has been used to determine the relative affinity of natural fatty acids for polymorphs of the Schistosoma mansoni Sm14 fatty acid-binding protein by...

PX-478 suppresses both constitutive and hypoxia-induced levels of HIF-1alpha in cancer cells, resulting in reduced expression of HIF-1alpha target genes. It induces apoptosis in human tumor xenografts in mice to an extent that is proportional to initial HIF-1alpha level. PX-478 can also increase chemo- or...