14 products were found matching "Cay101710"!

Peroxisome proliferator-activated receptor alpha (PPARalpha) is a member of the nuclear receptor family of ligand-activated transcription factors that regulates a variety of metabolic functions and inflammation. It contains an N-terminal domain that is subject to phosphorylation, a DNA-binding domain, and a...

Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively). Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively). Caspase inhibitors in the aldehyde...

Synonyms: Z03402103. Immunogen: purified eggshell proteins (zona radiata proteins and small amounts of zona pellucida proteins) from Atlantic salmon (S. salar). Clone Designation: MN-8C4. Formulation: (Request formulation change), Affinity-purified IgG in 0.1 M sodium phosphate, pH 7.4, containing 0.15 M sodium...

(+)-D-threo-PDMP is a ceramide analog and is one of the four possible stereoisomers of PDMP (Cay-62595). (+)-D-threo-PDMP is an inhibitor of glucosylceramide synthase. It inhibits glucosylceramide synthase by 50% when used at a concentration of 5 µM in an enzyme assay. (+)-D-threo-PDMP is the active component of...

BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses. It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1...

Numerous analogs of arachidonoyl ethanolamide (AEA, anandamide, Cay-90050) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons or inhibition of fatty acid amide hydrolase (FAAH) within the neurons. OMDM-1 is an endocannabinoid analog specifically...

Numerous analogs of arachidonoyl ethanolamide (AEA, anandamide, Cay-90050) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty acid amide hydrolase (FAAH) within the neurons. OMDM-2 is an endocannabinoid analog specifically...

PF-04691502 is an inhibitor of PI3Kalpha, -beta, -delta, and -gamma and mammalian target of rapamycin (mTOR, Kis = 1.8, 2.1, 1.6, 1.9, and 16 nM, respectively, for the human enzymes). It decreases the proliferation of BT-20 breast cancer, SKOV3 ovarian cancer, and U87MG glioblastoma cells (IC50s = 313, 188, and 179...

Nociceptive sensory peripheral neurons often express both heat sensitive (VR1) and cold-sensitive (CMR1 (rat), TRPM8 (human)) receptors that are part of the transient receptor potential (TRP) superfamily. Icilin is a synthetic CMR1/TRPM8 super agonist that is 2.5-fold more efficacious and nearly 200-fold more potent...

Polybiquitinylation designates proteins for proteasomal degradation. USP14 is one of several deubiquitinating enzymes (DUBs) responsible for shortening proteasome-bound ubiquitin chains, which is known to antagonize the degradation of ubiquitin-protein conjugates. IU1 is a reversible, small molecule inhibitor of...

Erucin is an isothiocyanate derived from glucoerucin, a glucosinolate predominant in arugula (Eruca sativa Mill.) and other cruciferous vegetables. At 2.5-5 µM erucin can induce significant neuroprotective and antioxidant effects, increasing both total glutathione levels and total antioxidant capacity at the...

Protein arginine N-methyltransferase 3 (PRMT3, Cay-11642) is a predominantly cytoplasmic enzyme that is constitutively expressed. SGC707 is a potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets. Developed by the Structural...