BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with Ki values of 0.4 and 0.6 µM from kinetic analyses. It is also a potent inhibitor of human arginase II with Ki values of 310 and 30 nM at pH 7.5 and 9.5, respectively. It does not inhibit murine iNOS at concentrations up to 1...

6-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It shares the vanillyl group found on capsaicin (Cay-92350) and, like capsaicin, activates the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.3 µM) as well as the TRP ankyrin receptor TRPA1 (EC50 = 10.4 µM). 6-Gingerol...