12 products were found matching "Cay10150"!

(R,S)-Anatabine is an alkaloid that has been found as a minor component in tobacco (Nicotiana). It is an agonist of alpha4beta2 and alpha6/alpha3beta2beta4 subunit-containing nicotinic acetylcholine receptors (nAChRs, EC50s = 6.1 and 3.6 µM, respectively). It is selective for alpha4beta2 and alpha6/alpha3beta2beta4...

rPLA2 is a calcium-dependent cytosolic phospholipase A2 (cPLA2) initially isolated and characterized from bovine and human red blood cells (RBCs). It has a molecular mass of 42 kDa and biochemical properties similar to cPLA2 Type IV. EA4 is a quinone derivative that inhibits rPLA2 with a Ki of 130 µM. It inhibits...

The CB1 receptor and the splice variant CB1a are localized mainly in the brain. The CB1 receptor is a G-protein coupled receptor that binds the active component of cannabis, Delta9-tetrahydrocannabinol. Human and rat CB1 receptors exhibit 97.3% homology at the amino acid level over the complete protein, and 100%...

The CB2 receptor is localized predominantly in peripheral tissues, including the spleen and hemopoietic cells. The CB1 and CB2 receptors are G-protein coupled receptors that bind the active component of cannabis, Delta9-tetrahydrocannabinol, as well as anandamide which is an endogenous CB receptor ligand. This...

Ramatroban is a dual TP and DP2/CRTH2 receptor antagonist (Kis = 4.5 and 4.3 nM for the human receptors, respectively). It is selective for these receptors over the prostaglandin E2 (PGE2) receptor subtypes EP1 and EP2, as well as the FP and IP receptors, at 1 µM. Ramatroban inhibits contractions induced by U-46619...

(±)12-HpETE is one of the six monohydroperoxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid (Cay-90010) and consists of an equal mixture of the R and S isomers. Reduction of the hydroperoxide yields the more stable hydroxyl fatty acid (±)12-HETE (Cay-34550). The biological activity of...

2,4-Dichlorophenoxy acetic acid is a synthetic auxin, a class of plant growth regulators, that is often used as a supplement in plant cell culture media. It is also an active ingredient in herbicides that controls root elongation and cell production by disrupting the actin cytoskeleton. Formulations containing...

trans-trismethoxy Resveratrol is a polyketide synthase-derived stilbene originally isolated from Virola cuspidata that has diverse biological activities. It is cytotoxic to several cancer cell lines, including PC3, KB, HT-29, SW480, and HL-60 cells (IC50s =3.6, 10.2, 16.1, 54, and 2.5 µM, respectively)....

Arachidonoyl ethanolamide (AEA, Cay-90050) was the first endogenous cannabinoid (CB) to be isolated and characterized as an agonist acting on the same receptors (CB1 and CB2) as THC. Since that time, a number of related endocannabinoids have been isolated, most notably 2-arachidonoyl glycerol (Cay-62160)....

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators. Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty...

N-Oleoyl dopamine (ODA) is a selective, endogenous vanilloid receptor 1 (VR1) agonist isolated from bovine brain. Structurally, it is the amide of oleic acid and dopamine and is therefore a "hybrid" analog which incorporates components of both the anandamide-like and dopamine neurotransmitter pathways. ODA binds to...

The biological effects of prostaglandin E2 (PGE2) are mediated through interaction with four distinct membrane-bound G-protein coupled EP receptors: EP1, EP2, EP3, and EP4. Binding of PGE2 to the EP2 receptor results in an increase in adenylate cyclase activity with a subsequent increase in cAMP. Pharmacologicially,...