11 products were found matching "Cay10080-%25"!

Inotilone is a cyclooxygenase (COX) inhibitor found in mushrooms of Phellinus and Inonotus sps. that inhibits COX-2 over COX-1 with IC50 values of 0.03 and 0.36 µM, respectively. It is a poor inhibitor of hydroxysteroid dehydrogenase and xanthine oxidase (IC50s = 50.4 and 9.1 µM, respectively). Inotilone...

(±)-Lisofylline (LSF) is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. LSF inhibits the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. LSF...

The phosphatidylinositols (PtdIns) phosphates represent a small precentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2 can be phosphorylated by phosphatidylinositol (PI)-3-kinase to make PtdIns-(3,4,5)-P3, which initiates...

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator...

1-Palmityl-2-hydroxy-sn-glycero-3-PA is an ether analog of lysophosphatidic acid (LPA) containing a hexadecyl group at the sn-1 position. LPA binds to five different G protein-coupled receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation,...

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2-fluorescein is a fluorescent probe for any protein with a high-affinity binding interaction with...

Lubiprostone is an activator of chloride channel protein 2 (ClC-2) and a bicyclic derivative of prostaglandin E1 (PGE1, Cay-13010). It induces chloride currents in HEK293 cells expressing recombinant human ClC-2 (EC50 = ~17 nM), but not CFTR, chloride channels. Lubiprostone (1 µM) induces short-circuit currents, a...

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D5 (RvD5) is a DHA-derived...

L-759,633 is a high-affinity peripheral cannabinoid receptor (CB2)-selective agonist with Ki values of 6.4 and 1,043 nM for CB2 and central cannabinoid (CB1) receptors, respectively. L-759,633 inhibits forskolin-stimulated cyclic AMP production in CHO cells transfected with CB2 or CB1 receptors with IC50 values of...

The peroxisome proliferator-activated receptors (PPARs) alpha, gamma, and delta are ligand-activated transcription factors that play a key role in lipid homeostasis. Activation of PPARalpha results in increased clearance of triglyceride (TG) rich very low-density lipoprotein (VLDL) via a reduction in plasma levels...

Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-Prostaglandin F2alpha (ent-8-iso-15(S)-PGF2alpha) is a potent...