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Onalespib
Onalespib

Item number: Cay10655-25

Onalespib is a selective inhibitor of Hsp90 (IC50 = 18 nM). It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo. Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft...
Keywords: AT-13387, [1,3-dihydro-5-[(4-methyl-1-piperazinyl)methyl]-2H-isoindol-2-yl][2,4-dihydroxy-5-(1-methylethyl)phenyl]-methanone
Application: Antineoplastic, Hsp90 inhibitor
CAS 912999-49-6
MW: 409.5 D
From 60.00€ *
Review
CAY10665
CAY10665

Item number: Cay11044-25

Isolated neonatal rat cardiomyocytes, which spontaneously beat in culture, are used to evaluate the antiarrhythmic effects of polyunsaturated fatty acids (PUFA). In this model, the omega-3 PUFA eicosapentaenoic acid (EPA, 3-10 µM) reduces the contraction rate of cells, indicating a positive antiarrhythmic effect....
Keywords: 16-[[2-(methylamino)-2-oxoacetyl]amino]-11Z-hexadecenoic acid
Application: 17,18-EET analog
CAS 1235543-17-5
MW: 354.5 D
From 65.00€ *
Review