4 products were found matching "Cay10043"!

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15(R)-Iloprost
15(R)-Iloprost

Item number: Cay10043-1

Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to the recombinant human IP and EP receptors with a Ki of 11 nM. 15(R)-Iloprost is the "unnatural"...
Keywords: 6,9alpha-methylene-11alpha,15R-dihydroxy-16-methyl-prosta-5E,13E-dien-18-yn-1-oic acid
Application: Bioactive lipid assays
CAS 85026-51-3
MW: 360.5 D
From 146.00€ *
Review
CAY10443
CAY10443

Item number: Cay10004177-10

Mitochondrial release of cytochrome c triggers apoptosis via the assembly of a multimeric complex including caspase-9, Apaf-1, and other components, sometimes called the apoptosome. Library screens have identified small molecules that activate the apoptosome by binding to one or more of its components. CAY10443 is...
Keywords: (S)-Indan-1-yl 3,4-dichlorobenzylcarbamate, [(3,4-dichlorophenyl)methyl]-carbamic acid, (1S)-2,3-dihydro-1H-inden-1-yl ester
Application: Caspase-3 activator
CAS 582314-48-5
MW: 336.2 D
From 66.00€ *
Review
SB939
SB939

Item number: Cay10443-5

SB939 is a pan-inhibitor of histone deacetylases (HDACs, Kis = 16-247 nM for HDAC1-11). It inhibits proliferation of A2780, COLO 205, HCT116, and PC3 cancer cells (IC50s = 0.48, 0.56, 0.48, and 0.34 µM, respectively). SB939 (50 and 100 mg/kg) reduces tumor growth and increases survival in an HCT116 mouse xenograft...
Keywords: Pracinostat, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2E-propenamide
Application: HDAC inhibitor
CAS 929016-96-6
MW: 358.5 D
From 60.00€ *
Review
BML-210
BML-210

Item number: Cay10005019-1

Inhibition of histone deacetylase (HDAC) enzymes by compounds such as trichostatin A can have wide ranging effects in cancer, cell differentiation, and other aspects of gene expression regulation. BML-210 is a small molecule inhibitor of HDAC with an IC50 value of 30 µM when tested in HeLa cell nuclear extracts...
Keywords: CAY10433, N-phenyl-N'-(2-Aminophenyl)hexamethylenediamide, N-(2-aminophenyl)-N'-phenyl-octanediamide
Application: HDAC inhibitor
CAS 537034-17-6
MW: 339.4 D
From 43.00€ *
Review