- Search results for Cay10022-%25
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6 products were found matching "Cay10022-%25"!
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Item number: Cay10009222-25
Sphingosine kinase isoforms, SPHK 1 and SPHK 2 , catalyze the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Sphingosine kinase inhibitor 2 is an...
Keywords: | SKI II, SPHK I2, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-phenol |
Application: | SPHK1 inhibitor |
CAS | 312636-16-1 |
MW: | 302.8 D |
From 54.00€
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Item number: Cay10012424-25
Leukotriene B4 (LTB4) promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, superoxide anion production, chemotaxis, and chemokinesis. Two G protein-coupled receptors, BLT1 and BLT2 mediate the actions of LTB4. CAY10583 is a potent, selective full agonist for BLT2 with an EC50...
Keywords: | 4'-[[(1-oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid |
Application: | BLT2 agonist |
CAS | 862891-27-8 |
MW: | 387.5 D |
From 82.00€
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Item number: Cay10010622-25
Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion. High levels of UCP2 expression can disrupt pancreatic beta cell function and downregulate insulin secretion thereby contributing to the...
Keywords: | (+)-Genipin, 1R,4aS,5,7aS-tetrahydro-1-hydroxy-7-(hydroxymethyl)-cyclopenta[c]pyran-4-carboxylic acid, methyl ester |
Application: | UCP2 inhibitor |
CAS | 6902-77-8 |
MW: | 226.2 D |
From 24.00€
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Item number: Cay10008822-25
Bortezomib is a dipeptide boronic acid derivative that reversibly inhibits the 20S proteasome (Ki = 0.6 nM). It binds the beta5-subunit of the 20S proteasome and selectively inhibits chymotryptic activity. In part by blocking the degradation of tumor-suppressing and proapoptotic proteins, bortezomib drives cell...
Keywords: | LDP-341, MG-341, MLN341, NSC 681239, PS-341,... |
Application: | Proteasome subunit beta type-1/5 inhibitor |
CAS | 179324-69-7 |
MW: | 384.2 D |
From 43.00€
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Item number: Cay10010422-25
Nilotinib is an inhibitor of wild-type and mutant Bcr-Abl (IC50s = 15 and 9-400 nM, respectively). It is selective for wild-type and mutant Bcr-Abl over Src and LYN (IC50s = >5,000 nM for both). Nilotinib inhibits Bcr-Abl autophosphorylation and cell proliferation in Ba/F3 cells expressing wild-type or mutant...
Keywords: | AMN107,... |
Application: | Bcr inhibitor, Abl inhibitor |
CAS | 641571-10-0 |
MW: | 529.5 D |
From 34.00€
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Item number: Cay10010522-25
U-46619 is a stable analog of the endoperoxide PGH2, and a TP receptor agonist. It exhibits properties similar to TXA2, causing platelet shape change, aggregation, and contraction of vascular smooth muscle. Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM respectively,...
Keywords: | 9,11-dideoxy-9alpha,11alpha-methanoepoxy-prosta-5Z,13E-dien-1-oic acid, methyl ester |
Application: | Bioactive lipid assays |
MW: | 421.6 D |
From 56.00€
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