- Search results for Cay10011424-%25
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12 products were found matching "Cay10011424-%25"!
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Item number: Cay10011344-25
Steviol is the aglycon derivative of steviol glycosides, which are natural sweeteners isolated from S. rebaudiana. Steviol inhibits human organic anion transporters (hOATs) in uptake assays using murine cells from the S2 segment of proximal tubules. It is selective for hOAT1 and hOAT3 over hOAT2 and hOAT4 (IC50s =...
Keywords: | Hydroxy Dehydrostevic Acid, NSC 226902, (4alpha)-13-hydroxy-kaur-16-en-18-oic acid |
Application: | OAT1 / OAT3 inhibitor |
CAS | 471-80-7 |
MW: | 318.5 D |
From 115.00€
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Item number: Cay10011432-25
CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal cytoplasmic tail of 28 amino acids, followed by a single 24 amino acid transmembrane region and an approximately 150 amino acid lumenal domain. The CD74 chain is thought to function mainly as a major histocompatibility complex...
Keywords: | Anti-Ii, Anti-p33, Anti-CD74, Anti-DHLAG, Anti-Ia antigen-associated invariant chain, Anti-HLA-DR antigens-associated... |
Application: | WB, IP, ICC, FC |
Host: | Mouse |
Species reactivity: | human |
From 158.00€
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Item number: Cay10011204-25
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators...
Keywords: | N-[(3S)-tetrahydro-2-oxo-3-thienyl]-butanamide |
Application: | Bioactive lipid assays |
CAS | 202284-85-3 |
MW: | 187.3 D |
From 60.00€
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Item number: Cay10011264-25
Casein Kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors, which lends promise as an anticancer drug target. CAY10578 is a potent inhibitor of CK2 with an...
Keywords: | 4,5,6,7-tetraiodo-1,3-dioxo-2-isoindolineacetic acid |
Application: | CK2 inhibitor |
CAS | 19231-60-8 |
MW: | 708.8 D |
From 24.00€
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Item number: Cay10012424-25
Leukotriene B4 (LTB4) promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, superoxide anion production, chemotaxis, and chemokinesis. Two G protein-coupled receptors, BLT1 and BLT2 mediate the actions of LTB4. CAY10583 is a potent, selective full agonist for BLT2 with an EC50...
Keywords: | 4'-[[(1-oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid |
Application: | BLT2 agonist |
CAS | 862891-27-8 |
MW: | 387.5 D |
From 82.00€
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Item number: Cay10011124-25
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in...
Keywords: | CF 233 (hydrochloride), N,3,4,5-tetrahydroxy-benzenecarboximidamide, monohydrochloride |
Application: | Ribonucleotide reductase inhibitor |
CAS | 95933-75-8 |
MW: | 220.6 D |
From 86.00€
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Item number: Cay10011724-25
Propenyl-L-NIO (hydrochloride) (ENIPO) is a potent, selective inhibitor of iNOS. The Ki values for inhibition of iNOS, nNOS, and eNOS by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics. However, ENIPO is a time-dependent inhibitor that, with longer incubations,...
Keywords: | ENIPO, N5-[(3E)-1-imino-3-pentenyl]-L-ornithine, monohydrochloride |
Application: | iNOS inhibitor |
MW: | 249.7 D |
From 77.00€
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Item number: Cay10011490-25
Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM). It is a very weak inhibitor of PP2B (IC50 > 2 µM) and does...
Keywords: | 35-demethyl DTX1, Acanthifolicin, NSC 677083, OA,... |
Application: | PP1 PP2A PP3 inhibitor |
CAS | 78111-17-8 |
MW: | 805 D |
From 77.00€
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Item number: Cay10011453-25
Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes. LXA5 slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4. However, LXA5 does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA4 and LXB4.Formal Name:...
Keywords: | LXA5, 5S,6R,15S-trihydroxy-7E,9E,11Z,13E,17Z-eicosapentaenoic acid |
Application: | Bioactive lipid assays |
CAS | 110657-98-2 |
MW: | 350.5 D |
From 374.00€
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Item number: Cay10011499-25
Phytanic acid is a saturated 20-carbon branched-chain fatty acid that can only be derived from dietary sources. Under normal conditions, phytanic acid is degraded via alpha-oxidation (oxidative decarboxylation) to produce pristanic acid, which then undergoes beta-oxidation as part of the metabolism process....
Keywords: | Phytanic Acid Coenzyme A Ester (triethylammonium salt), phytanoyl-CoA (triethylammonium salt),... |
Application: | Metabolic studies |
MW: | 1365.6 D |
From 110.00€
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Item number: Cay10011914-25
Deoxynojirimycin (dNM) tetrabenzyl ether is an intermediate for the synthesis of glucosylceramide synthase inhibitors such as 1-dNM, a glucose analog that potently inhibits alpha-glucosidase I and II.Formal Name: 3R,4R,5S-tris(phenylmethoxy-2R-[(phenylmethoxy)methyl]-piperidine. CAS Number: 69567-11-9. Synonyms: DNJ...
Keywords: | DNJ Tetrabenzyl Ether, dNM Tetrabenzyl Ether, 3R,4R,5S-tris(phenylmethoxy-2R-[(phenylmethoxy)methyl]-piperidine |
Application: | Alpha-glucosidase inhibitor |
CAS | 69567-11-9 |
MW: | 523.7 D |
From 100.00€
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Item number: Cay10011054-25
The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), promote the reduction of plasma cholesterol levels and induce weight loss. However when administered in high doses, thyroid hormones produce undesirable side effects in the heart, bone and muscle. KB2115 is a synthetic thyroid hormone mimetic. At a dose...
Keywords: | Eprotirome, 3-[[3,5-dibromo-4-[4-hydroxy-3-(1-methylethyl)phenoxy]phenyl]amino-3-oxo-propanoic acid |
Application: | Thyroid hormone mimetic |
CAS | 355129-15-6 |
MW: | 487.1 D |
From 66.00€
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