- Search results for Cay10011422-%25
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14 products were found matching "Cay10011422-%25"!
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Item number: Cay10011432-25
CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal cytoplasmic tail of 28 amino acids, followed by a single 24 amino acid transmembrane region and an approximately 150 amino acid lumenal domain. The CD74 chain is thought to function mainly as a major histocompatibility complex...
Keywords: | Anti-Ii, Anti-p33, Anti-CD74, Anti-DHLAG, Anti-Ia antigen-associated invariant chain, Anti-HLA-DR antigens-associated... |
Application: | WB, IP, ICC, FC |
Host: | Mouse |
Species reactivity: | human |
From 158.00€
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Item number: Cay10011204-25
Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. Controlling bacterial infections by quenching their quorum sensing systems is a promising field of study. The expression of specific target genes, such as transcriptional regulators...
Keywords: | N-[(3S)-tetrahydro-2-oxo-3-thienyl]-butanamide |
Application: | Bioactive lipid assays |
CAS | 202284-85-3 |
MW: | 187.3 D |
From 60.00€
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Item number: Cay10011124-25
Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in...
Keywords: | CF 233 (hydrochloride), N,3,4,5-tetrahydroxy-benzenecarboximidamide, monohydrochloride |
Application: | Ribonucleotide reductase inhibitor |
CAS | 95933-75-8 |
MW: | 220.6 D |
From 86.00€
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Item number: Cay10011264-25
Casein Kinase 2 (CK2) is a constitutive protein kinase involved in many signal transduction pathways. CK2 is known to negatively regulate apoptosis, and its activity is increased in many proliferating tissues and tumors, which lends promise as an anticancer drug target. CAY10578 is a potent inhibitor of CK2 with an...
Keywords: | 4,5,6,7-tetraiodo-1,3-dioxo-2-isoindolineacetic acid |
Application: | CK2 inhibitor |
CAS | 19231-60-8 |
MW: | 708.8 D |
From 24.00€
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Item number: Cay10011724-25
Propenyl-L-NIO (hydrochloride) (ENIPO) is a potent, selective inhibitor of iNOS. The Ki values for inhibition of iNOS, nNOS, and eNOS by ENIPO are 17, 10.3 and 58.2 µM, respectively, as determined using initial rate binding kinetics. However, ENIPO is a time-dependent inhibitor that, with longer incubations,...
Keywords: | ENIPO, N5-[(3E)-1-imino-3-pentenyl]-L-ornithine, monohydrochloride |
Application: | iNOS inhibitor |
MW: | 249.7 D |
From 77.00€
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Item number: Cay10011248-25
CAY10575 inhibits IKKbeta and polo-like kinase 1 (Plk1, IC50s = 0.075 and 0.125 µM, respectively). It also inhibits IKKepsilon (IC50 = 95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1mg/mL, DMSO: 10mg/mL, DMSO:PBS(7.2pH) 1:4: 0.2mg/mL. lambdamax: 295 nm. SMILES:...
Keywords: | 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide |
Application: | IKKepsilon inhibitor |
CAS | 916985-21-2 |
MW: | 487.6 D |
From 52.00€
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Item number: Cay10011246-25
Janus kinase 3 (JAK3) is a cytoplasmic protein tyrosine kinase that functions in the initiation of cytokine-triggered signal transduction by catalyzing the phosphorylation of signal transduction and activators of transcription (STATs). JAK3 is abundantly expressed in normal lymphoid cells as well as human...
Keywords: | Janex 1, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-phenol |
Application: | JAK3 inhibitor |
CAS | 202475-60-3 |
MW: | 297.3 D |
From 42.00€
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Item number: Cay10010422-25
Nilotinib is an inhibitor of wild-type and mutant Bcr-Abl (IC50s = 15 and 9-400 nM, respectively). It is selective for wild-type and mutant Bcr-Abl over Src and LYN (IC50s = >5,000 nM for both). Nilotinib inhibits Bcr-Abl autophosphorylation and cell proliferation in Ba/F3 cells expressing wild-type or mutant...
Keywords: | AMN107,... |
Application: | Bcr inhibitor, Abl inhibitor |
CAS | 641571-10-0 |
MW: | 529.5 D |
From 34.00€
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Item number: Cay10011490-25
Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A (IC50 = 0.5 nM) and PP3 (IC50 = 4 nM). It is a very weak inhibitor of PP2B (IC50 > 2 µM) and does...
Keywords: | 35-demethyl DTX1, Acanthifolicin, NSC 677083, OA,... |
Application: | PP1 PP2A PP3 inhibitor |
CAS | 78111-17-8 |
MW: | 805 D |
From 77.00€
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Item number: Cay10011453-25
Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes. LXA5 slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4. However, LXA5 does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA4 and LXB4.Formal Name:...
Keywords: | LXA5, 5S,6R,15S-trihydroxy-7E,9E,11Z,13E,17Z-eicosapentaenoic acid |
Application: | Bioactive lipid assays |
CAS | 110657-98-2 |
MW: | 350.5 D |
From 374.00€
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Item number: Cay10011499-25
Phytanic acid is a saturated 20-carbon branched-chain fatty acid that can only be derived from dietary sources. Under normal conditions, phytanic acid is degraded via alpha-oxidation (oxidative decarboxylation) to produce pristanic acid, which then undergoes beta-oxidation as part of the metabolism process....
Keywords: | Phytanic Acid Coenzyme A Ester (triethylammonium salt), phytanoyl-CoA (triethylammonium salt),... |
Application: | Metabolic studies |
MW: | 1365.6 D |
From 110.00€
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Item number: Cay10011914-25
Deoxynojirimycin (dNM) tetrabenzyl ether is an intermediate for the synthesis of glucosylceramide synthase inhibitors such as 1-dNM, a glucose analog that potently inhibits alpha-glucosidase I and II.Formal Name: 3R,4R,5S-tris(phenylmethoxy-2R-[(phenylmethoxy)methyl]-piperidine. CAS Number: 69567-11-9. Synonyms: DNJ...
Keywords: | DNJ Tetrabenzyl Ether, dNM Tetrabenzyl Ether, 3R,4R,5S-tris(phenylmethoxy-2R-[(phenylmethoxy)methyl]-piperidine |
Application: | Alpha-glucosidase inhibitor |
CAS | 69567-11-9 |
MW: | 523.7 D |
From 100.00€
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