13 products were found matching "Cay10010750"!

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(-)-Deguelin
(-)-Deguelin

Item number: Cay10010706-50

(-)-Deguelin is a rotenoid that has been found in T. vogelii and has diverse biological activities. It inhibits mitochondrial complex I, also known as NADH dehydrogenase, activity in bovine heart electron transport particles and phorbol 12-myristate 13-acetate-induced ornithine decarboxylase (ODC) activity in MCF-7...
Keywords: (-)-cis-Deguelin, 13,13aS-dihydro-9,10-dimethoxy-3,3-dimethyl-3H-[1]benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aS)-one
Application: Chemopreventive effector
CAS 522-17-8
MW: 394.4 D
From 70.00€ *
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(±)-Lisofylline
(±)-Lisofylline

Item number: Cay10010785-50

(±)-Lisofylline (LSF) is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. LSF inhibits the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. LSF...
Keywords: BL 194, CT-1501R, LSF, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6-dione
Application: Phosphatidic acid generation inhibitor
CAS 6493-06-7
MW: 280.3 D
From 98.00€ *
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Prostaglandin A1
Prostaglandin A1

Item number: Cay10010-50

Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients. It also has growth-inhibitory activity on tumor cells, the IC50...
Keywords: PGA1, 9-oxo-15S-hydroxy-prosta-10,13E-dien-1-oic acid
Application: Bioactive lipid assays
CAS 14152-28-4
MW: 336.5 D
From 48.00€ *
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Fluvastatin (sodium salt hydrate)
Fluvastatin (sodium salt hydrate)

Item number: Cay10010337-50

Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Keywords: 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid, sodium salt, hydrate
Application: Hydroxymethylglutaryl-coenzyme A reductase inhibitor
MW: 410.5 D
From 35.00€ *
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beta-cyano-L-Alanine
beta-cyano-L-Alanine

Item number: Cay10010947-50

Hydrogen sulfide (H2S) is a naturally-occurring gasotransmitter with vasodilator and inflammatory modulating activity. H2S is synthesized naturally in a range of mammalian tissues principally by the activity of two enzymes, cystathionine gamma lyase (CSE) and cystathionine beta synthetase (CBS). beta-cyano-L-Alanine...
Keywords: BCA, 3-cyano-L-alanine
Application: CSE inhibitor
CAS 6232-19-5
MW: 114.1 D
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N-(beta-ketocaproyl)-L-Homoserine lactone
N-(beta-ketocaproyl)-L-Homoserine lactone

Item number: Cay10011207-50

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. This regulatory process manifests itself with a variety of phenotypes including biofilm formation and virulence factor production. Coordinated gene expression is achieved by the production,...
Keywords: 3-O-C6-(L)-HSL, 3-oxo-N-[(3S)-tetrahydro-2-oxo-3-furanyl]-hexanamide
Application: Antibiotic
CAS 143537-62-6
MW: 213.2 D
From 40.00€ *
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O-Arachidonoyl Glycidol
O-Arachidonoyl Glycidol

Item number: Cay10010547-50

2-Arachidonoyl glycerol (2-AG) is an endogenous ligand that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors and is involved in the regulation of a broad range of neurotransmitter signalling functions with implications in neurodegenerative diseases, pain, cancer, and obesity. Levels...
Keywords: 5Z,8Z,11Z,14Z-eicosatetraenoic acid, oxiranylmethyl ester
Application: Fatty acid amide hydrolase inhibitor
CAS 439146-24-4
MW: 360.5 D
From 110.00€ *
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17(R)-HETE
17(R)-HETE

Item number: Cay10010637-50

Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. 17-HETE is a cytochrome P450 (CYP450) metabolite of arachidonic acid that has stereospecific...
Keywords: 17R-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
Application: Bioactive lipid assays
CAS 183509-24-2
MW: 320.5 D
From 196.00€ *
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CB-52
CB-52

Item number: Cay10010117-50

CB-52 is a stable analog of Delta9-tetrahydrocannabinol (THC) and anandamide (AEA). It exhibits high affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 210 and 30 nM, respectively. In vitro, CB-52 behaves primarily as a CB1 receptor partial agonist and a CB2...
Keywords: N-cyclopropyl-11-(2-hexyl-5-hydroxyphenoxy)-undecanamide
Application: CB1 receptor partial agonist, CB2 receptor neutral antagonist
CAS 869376-90-9
MW: 417.6 D
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SC-514
SC-514

Item number: Cay10010267-50

SC-514 is a selective and reversible inhibitor of IkappaB kinase 2 (IKK2) (IC50 = 3-12 µM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. In synovial fibroblasts stimulated with interleukin (IL)-1beta, SC-514 attenuates NF-kappaB-mediated expression of IL-6,...
Keywords: 4-amino-[2,3'-bithiophene]-5-carboxamide
Application: IKK2 inhibitor
CAS 354812-17-2
MW: 224.3 D
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BIBB 515
BIBB 515

Item number: Cay10010517-50

2,3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S)-2,3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of...
Keywords: 1-(4-chlorobenzoyl)-4-[[4-(4,5-dihydro-2-oxazolyl)phenyl]methylene]-piperidine
Application: OSC inhibitor
CAS 156635-05-1
MW: 380.9 D
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PF-622
PF-622

Item number: Cay10010907-50

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-622 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values of 0.99 and 0.033 µM when preincubated with human recombinant FAAH for 5 and 60 minutes,...
Keywords: N-phenyl-4-(2-quinolinylmethyl)-1-piperazinecarboxamide
Application: FAAH inhibitor
CAS 898235-65-9
MW: 346.4 D
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