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14,15-EE-8(Z)-E
14,15-EE-8(Z)-E

Item number: Cay10010486-25

Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator...
Keywords: 14,15-Epoxyeicosa-8(Z)-enoic Acid, 13[(2R,3S)-3-pentyloxiranyl]-8Z-tridecenoic acid
Application: Vasodilator agonist
CAS 519038-93-8
MW: 324.5 D
From 65.00€ *
Review
Lubiprostone
Lubiprostone

Item number: Cay10010487-25

Lubiprostone is an activator of chloride channel protein 2 (ClC-2) and a bicyclic derivative of prostaglandin E1 (PGE1, Cay-13010). It induces chloride currents in HEK293 cells expressing recombinant human ClC-2 (EC50 = ~17 nM), but not CFTR, chloride channels. Lubiprostone (1 µM) induces short-circuit currents, a...
Keywords: RU-0211, SPI-0211, 16,16-difluoro-11alpha-hydroxy-9,15-dioxo-prostan-1-oic acid
Application: ClC-2 activator
CAS 136790-76-6
MW: 390.5 D
From 84.00€ *
Review