3 products were found matching "Cay10010427-%25"!
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Lubiprostone
Item number: Cay10010487-25
Lubiprostone is an activator of chloride channel protein 2 (ClC-2) and a bicyclic derivative of prostaglandin E1 (PGE1, Cay-13010). It induces chloride currents in HEK293 cells expressing recombinant human ClC-2 (EC50 = ~17 nM), but not CFTR, chloride channels. Lubiprostone (1 µM) induces short-circuit currents, a...
| Keywords: | RU-0211, SPI-0211, 16,16-difluoro-11alpha-hydroxy-9,15-dioxo-prostan-1-oic acid |
| Application: | ClC-2 activator |
| CAS | 136790-76-6 |
| MW: | 390.5 D |
From 84.00€
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Nilotinib
Item number: Cay10010422-25
Nilotinib is an inhibitor of wild-type and mutant Bcr-Abl (IC50s = 15 and 9-400 nM, respectively). It is selective for wild-type and mutant Bcr-Abl over Src and LYN (IC50s = >5,000 nM for both). Nilotinib inhibits Bcr-Abl autophosphorylation and cell proliferation in Ba/F3 cells expressing wild-type or mutant...
| Keywords: | AMN107,... |
| Application: | Bcr inhibitor, Abl inhibitor |
| CAS | 641571-10-0 |
| MW: | 529.5 D |
From 34.00€
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SC-51322
Item number: Cay10010744-25
The prostaglandin E2 (PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a mouse writhing...
| Keywords: | 8-chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]hydrazide, dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid |
| Application: | EP1 antagonist |
| CAS | 146032-79-3 |
| MW: | 457.9 D |
From 27.00€
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