17 products were found matching "Cay10010425-%25"!
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Nilotinib
Item number: Cay10010422-25
Nilotinib is an inhibitor of wild-type and mutant Bcr-Abl (IC50s = 15 and 9-400 nM, respectively). It is selective for wild-type and mutant Bcr-Abl over Src and LYN (IC50s = >5,000 nM for both). Nilotinib inhibits Bcr-Abl autophosphorylation and cell proliferation in Ba/F3 cells expressing wild-type or mutant...
| Keywords: | AMN107,... |
| Application: | Bcr inhibitor, Abl inhibitor |
| CAS | 641571-10-0 |
| MW: | 529.5 D |
From 34.00€
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15-keto-17-phenyl trinor Prostaglandin F2alpha ethyl amide
Item number: Cay10010405-25
Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2alpha ethyl amide (17-phenyl trinor PGF2alpha ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2alpha ethyl amide....
| Keywords: | 15-keto-Bimatoprost, 17-phenyl trinor PGF2alpha ethyl amide,... |
| Application: | F-series PG analog |
| CAS | 1163135-96-3 |
| MW: | 413.5 D |
From 92.00€
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LY223982
Item number: Cay10010024-25
Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT1 receptor antagonist. It inhibits the specific binding of...
| Keywords: | CGS 23131, SKF 107324, 5-(3-carboxybenzoyl)-2-[[(5E)-6-(4-methoxyphenyl)-5-hexenyl]oxy]-benzenepropanoic acid |
| Application: | BLT1 receptor antagonist |
| CAS | 117423-74-2 |
| MW: | 502.6 D |
From 38.00€
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AG-1478
Item number: Cay10010244-25
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTK. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor receptor (EGFR) kinase and block...
| Keywords: | NSC 693255, Tyrphostin AG-1478, N-(3-chlorophenyl)-6,7-dimethoxy-4-quinazolinamine |
| Application: | EGF receptor kinase inhibitor |
| CAS | 153436-53-4 |
| MW: | 315.8 D |
From 30.00€
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ADHP
Item number: Cay10010469-25
ADHP is a highly sensitive, stable substrate for horseradish peroxidase (HRP) that enables selective detection of H2O2. This colorless, non-fluorescent reagent reacts with H2O2 to produce the fluorescent compound resorufin, which can be analyzed using an excitation wavelength of 520-550 nm and an emission wavelength...
| Keywords: | A 6550, ADHP, Amplex Red(R), 1-(3,7-dihydroxy-10H-phenoxazin-10-yl)-ethanone |
| Application: | HRP substrate |
| CAS | 119171-73-2 |
| MW: | 257.2 D |
From 34.00€
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SP600125
Item number: Cay10010466-25
SP6000125 is a pan-inhibitor of JNK (IC50s = 0.04, 0.04, and 0.09 µM for JNK1, -2, and -3, respectively). It is greater than 300-fold selective for these enzymes over a panel of 17 additional kinases at 10 µM. SP6000125 reduces LPS-induced production of IL-1beta, IL-8, and TNF-alpha in isolated human peripheral...
| Keywords: | 1PMV, NSC 75890, Pyrazolanthrone, anthra[1,9-cd]pyrazol-6(2H)-one |
| Application: | JNK inhibitor |
| CAS | 129-56-6 |
| MW: | 220.2 D |
From 60.00€
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CAY10571
Item number: Cay10010400-25
Pyridinylimidazoles, often termed CSAIDs, are a class of anti-inflammatory compounds that inhibit eicosanoid production and suppress the synthesis of cytokines in human monocytes. Because of its high specificity, one predominant pyridinylimidazole, SB203580, is frequently used to inhibit p38 MAPK, the tyrosine...
| Keywords: | 4-[5-(4-fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]-pyridine |
| Application: | p38 MAPK inhibitor |
| CAS | 152121-46-5 |
| MW: | 393.4 D |
From 64.00€
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14,15-EE-8(Z)-E
Item number: Cay10010486-25
Epoxyeicosatrienoic acids (EETs), such as 11(12)-EET and 14(15)-EET, are cytochrome P450 metabolites of arachidonic acid that have been identified as endothelium-derived hyperpolarizing factors with vasodilator activity. 14,15-EE-8(Z)-E is a structural analog of 14(15)-EET that demonstrates potent vasodilator...
| Keywords: | 14,15-Epoxyeicosa-8(Z)-enoic Acid, 13[(2R,3S)-3-pentyloxiranyl]-8Z-tridecenoic acid |
| Application: | Vasodilator agonist |
| CAS | 519038-93-8 |
| MW: | 324.5 D |
From 65.00€
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Lubiprostone
Item number: Cay10010487-25
Lubiprostone is an activator of chloride channel protein 2 (ClC-2) and a bicyclic derivative of prostaglandin E1 (PGE1, Cay-13010). It induces chloride currents in HEK293 cells expressing recombinant human ClC-2 (EC50 = ~17 nM), but not CFTR, chloride channels. Lubiprostone (1 µM) induces short-circuit currents, a...
| Keywords: | RU-0211, SPI-0211, 16,16-difluoro-11alpha-hydroxy-9,15-dioxo-prostan-1-oic acid |
| Application: | ClC-2 activator |
| CAS | 136790-76-6 |
| MW: | 390.5 D |
From 84.00€
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Simvastatin
Item number: Cay10010344-25
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
| Keywords: | MK-733,... |
| Application: | HMG-CoA reductase inhibitor |
| CAS | 79902-63-9 |
| MW: | 418.6 D |
From 43.00€
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Fluvastatin
Item number: Cay10010334-25
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
| Keywords: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid |
| Application: | HMG-CoA reductase inhibitor |
| CAS | 93957-54-1 |
| MW: | 411.5 D |
From 54.00€
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AG-213
Item number: Cay10010314-25
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
| Keywords: | Tyrphostin 47, Tyrphostin AG-213, 2-cyano-3-(3,4-dihydroxyphenyl)-2E-propenethioamide |
| Application: | EGF receptor kinase inhibitor |
| CAS | 122520-86-9 |
| MW: | 220.2 D |
From 77.00€
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