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NS-304 | CAS 475086-01-2

ART NR.: Cay10010411-1 (1 mg)
Cay10010411-5 (5 mg)
Cay10010411-10 (10 mg)
Cay10010411-50 (50 mg)

Hersteller: Cayman



Anwendungen: IP receptor agonist

CAS-Nr. : 475086-​01-​2 | Suche mit CAS-Nr.

MW: 496 D

Formel: C28H32N4O4S

Reinheit: >98%

Format: solution

Lagerung: -20°C

Versand: -20°C

Schlagworte: 2-(4-((5,6-diphenylpyrazinyl)(1-methylethyl)amino)butoxy)-N-(methylsulfonyl)-acetamide


1 mg

49 €


5 mg

204 €


10 mg

359 €


50 mg

1555 €

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Bemerkungen: Prostaglandin I2 (PGI2) is a potent vasorelaxant and inhibitor of human platelet aggregation that mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells and platelets. The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation. NS-304 is a prodrug of the active form of MRE-269, which is a potent and selective agonist for the human IP receptor with a Ki value of 20 nM. In contrast to PGI2, which has a half-life of 30 seconds to a few minutes in vivo, NS-304 is long-acting. Plasma concentrations of MRE-269 remain near peak levels for more than eight hours in rats and dogs after NS-304 was administered orally.
Image Art Cay10010411-1 Cayman NS-304

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