8 products were found matching "Cay10010382-%25"!

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PtdIns-(3,4,5)-P3-fluorescein (triethylammonium salt)
PtdIns-(3,4,5)-P3-fluorescein (triethylammonium salt)

Item number: Cay10010383-25

The phosphatidylinositols (PtdIns) phosphates represent a small precentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2 can be phosphorylated by phosphatidylinositol (PI)-3-kinase to make PtdIns-(3,4,5)-P3, which initiates...
Keywords: 1-(1-octadecanoyl-fluorescein-2R-octanoylphosphatidyl)inositol-3,4,5-trisphosphate, heptatriethylammonium salt
Application: Bioactive lipid assays
MW: 1908.2 D
From 115.00€ *
Review
ent-8-iso-15(S)-Prostaglandin F2alpha
ent-8-iso-15(S)-Prostaglandin F2alpha

Item number: Cay10010380-25

Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-Prostaglandin F2alpha (ent-8-iso-15(S)-PGF2alpha) is a potent...
Keywords: ent-15-epi-F2t-Isoprostane, ent-8-iso-15-epi-PGF2alpha, 9beta,11beta,15S-trihydroxy-(12beta)-prosta-5Z,13E-dien-1-oic acid
Application: Bioactive lipid assays
CAS 214748-66-0
MW: 354.5 D
From 161.00€ *
Review
PtdIns-(4,5)-P2-fluorescein (triethylammonium salt)
PtdIns-(4,5)-P2-fluorescein (triethylammonium salt)

Item number: Cay10010388-25

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2-fluorescein is a fluorescent probe for any protein with a high-affinity binding interaction with...
Keywords: 1-(1-octadecanoyl-fluorescein-2R-octadecanoylphosphatidyl)inositol-4,5-bisphosphate, pentatriethylammonium salt
Application: Bioactive lipid assays
MW: 1625.8 D
From 115.00€ *
Review
GW 5074
GW 5074

Item number: Cay10010368-25

Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway. This pathway mediates basic cellular functions, including proliferation, differentiation, and survival. GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM). It blocks...
Keywords: 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one
Application: Raf-1 inhbitor
CAS 220904-83-6
MW: 520.9 D
From 50.00€ *
Review
CB-13
CB-13

Item number: Cay10010398-25

CB-13 is a dual agonist of the CB1 (IC50 = 15 nM) and CB2 (IC50 = 98 nM) receptors. In rats, oral CB-13 (3 mg/kg) potently blocks CB1-dependent neuropathic mechanical hyperalgesia, shows limited brain penetration, and exhibits good oral bioavailability. CB-13 does not possess genotoxic potential, as indicated by...
Keywords: CRA-13, 1-naphthalenyl[4-(pentylox)-1-naphthalenyl]-methanone
Application: Dual CB1 / CB2 receptor agonist
CAS 432047-72-8
MW: 368.5 D
From 74.00€ *
Review
AG-82
AG-82

Item number: Cay10010312-25

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
Keywords: NSC 676484, RG-50875, Tyrphostin 25, Tyrphostin AG-82, 2-[(3,4,5-trihydroxyphenyl)methylene]-propanedinitrile
Application: EGF receptor kinase inhibitor
CAS 118409-58-8
MW: 202.2 D
From 38.00€ *
Review
GW 842166X
GW 842166X

Item number: Cay10010372-25

GW 842166X is a cannabinoid 2 (CB2) receptor agonist. It increases intracellular calcium mobilization induced by the CB receptor agonist CP 55,940 (Cay-13241) in HEK cells co-expressing a chimeric Galphaq/05 protein and the human CB2 receptor (EC50 = 7.78 µM). GW 842166X is selective for CB2 over the CB1 receptor...
Keywords: 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Application: CB2 receptor agonist
CAS 666260-75-9
MW: 449.3 D
From 30.00€ *
Review
(±)18-HETE
(±)18-HETE

Item number: Cay10010638-25

(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, whereas 18(S)-HETE does not affect perfusion pressure. 18-HETE has...
Keywords: (±)18-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid
Application: Bioactive lipid assays
CAS 133268-58-3
MW: 320.5 D
From 196.00€ *
Review