7 products were found matching "Cay10010375-%25"!
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GW 842166X
Item number: Cay10010372-25
GW 842166X is a cannabinoid 2 (CB2) receptor agonist. It increases intracellular calcium mobilization induced by the CB receptor agonist CP 55,940 (Cay-13241) in HEK cells co-expressing a chimeric Galphaq/05 protein and the human CB2 receptor (EC50 = 7.78 µM). GW 842166X is selective for CB2 over the CB1 receptor...
| Keywords: | 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| Application: | CB2 receptor agonist |
| CAS | 666260-75-9 |
| MW: | 449.3 D |
From 30.00€
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(S)-Equol
Item number: Cay10010173-25
(S)-Equol is an agonist of estrogen receptor alpha (ERalpha) and ERbeta and an active metabolite of the polyketide isoflavone daidzein (Cay-10005166). It is formed from daidzein by gut microbiota. (S)-Equol induces ERalpha-and ERbeta-mediated gene transcription in HEC-1 cells expressing the human receptors in a...
| Keywords: | (-)-Equol, 4',7-Dihydroxyisoflavan, 4',7-Isoflavandiol, (S)-3,4-dihydro-3-(4-hydroxyphenyl)-2H-1-benzopyran-7-ol |
| Application: | ERbeta agonist |
| CAS | 531-95-3 |
| MW: | 242.3 D |
From 28.00€
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Fluvastatin (sodium salt hydrate)
Item number: Cay10010337-25
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
| Keywords: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid, sodium salt, hydrate |
| Application: | Hydroxymethylglutaryl-coenzyme A reductase inhibitor |
| MW: | 410.5 D |
From 35.00€
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ZM 336372
Item number: Cay10010367-25
The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a...
| Keywords: | 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide |
| Application: | Raf-1 inhibitor |
| CAS | 208260-29-1 |
| MW: | 389.4 D |
From 58.00€
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AG-183
Item number: Cay10010315-25
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
| Keywords: | Tyrphostin 51, 2-amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile |
| Application: | EGF receptor kinase inhibitor |
| CAS | 122520-90-5 |
| MW: | 268.2 D |
From 54.00€
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Simvastatin (sodium salt)
Item number: Cay10010345-25
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
| Keywords: | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-nap... |
| Application: | Inhibitor of HMG-CoA reductase |
| CAS | 101314-97-0 |
| MW: | 458.6 D |
From 48.00€
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CJ-023423
Item number: Cay10010355-25
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki =...
| Keywords: | Grapiprant, RQ-00000007,... |
| Application: | EP4R antagonist |
| CAS | 415903-37-6 |
| MW: | 491.6 D |
From 43.00€
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