- Search results for Cay10010365-%25
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7 products were found matching "Cay10010365-%25"!
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Item number: Cay10010367-25
The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a...
Keywords: | 3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]-benzamide |
Application: | Raf-1 inhibitor |
CAS | 208260-29-1 |
MW: | 389.4 D |
From 58.00€
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Item number: Cay10010368-25
Raf-1 is a proto-oncogene serine/threonine protein kinase that signals from Ras to the MAPK/ERK signaling pathway. This pathway mediates basic cellular functions, including proliferation, differentiation, and survival. GW 5074 is a potent, selective, and cell-permeable inhibitor of Raf-1 (IC50 = 9 nM). It blocks...
Keywords: | 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-2H-indol-2-one |
Application: | Raf-1 inhbitor |
CAS | 220904-83-6 |
MW: | 520.9 D |
From 50.00€
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Item number: Cay10010396-25
TPalpha and TPbeta are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucidated, TPbeta is believed to be responsible for vascular endothelial growth factor-induced...
Keywords: | N-(tert-butylcarbamoyl)-2-(3-methoxyphenoxy)-5-nitrobenzenesulfonamide |
Application: | TP receptor antagonist |
CAS | 945716-28-9 |
MW: | 423.4 D |
From 48.00€
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Item number: Cay10010635-25
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE...
Keywords: | (±)16-hydroxy-5Z,8Z,11Z,14Z-eicosatetraenoic acid |
Application: | Bioactive lipid assays |
CAS | 128914-46-5 |
MW: | 320.5 D |
From 196.00€
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Item number: Cay10010315-25
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
Keywords: | Tyrphostin 51, 2-amino-4-(3,4,5-trihydroxyphenyl)-1,3-butadiene-1,1,3-tricarbonitrile |
Application: | EGF receptor kinase inhibitor |
CAS | 122520-90-5 |
MW: | 268.2 D |
From 54.00€
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Item number: Cay10010345-25
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-nap... |
Application: | Inhibitor of HMG-CoA reductase |
CAS | 101314-97-0 |
MW: | 458.6 D |
From 48.00€
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Item number: Cay10010355-25
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CJ-023423 is a potent and selective antagonist of the EP4 receptor (Ki =...
Keywords: | Grapiprant, RQ-00000007,... |
Application: | EP4R antagonist |
CAS | 415903-37-6 |
MW: | 491.6 D |
From 43.00€
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