29 products were found matching "Cay10010350"!

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CCG-1423
CCG-1423

Item number: Cay10010350-5

The Rho family of small GTPases play an important role in transduction of cell signaling events associated with several human cancers. CCG-1423 is a specific inhibitor of Rho pathway-mediated signaling and activation of serum response factor (SRF) transcription. It inhibits SRF-driven luciferase expression in PC-3...
Keywords: N-[2-[4(4-chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)-benzamide
Application: Rho pathway inhibitor
CAS 285986-88-1
MW: 454.8 D
From 66.00€ *
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6alpha-Testosterone Enanthate
6alpha-Testosterone Enanthate

Item number: Cay10010003-500

6alpha-Testosterone enanthate (Cay-10010003) is an analytical reference standard that is structurally similar to known anabolic androgenic steroids. 6alpha-Testosterone enanthate is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications.Formal Name:...
Keywords: 6S-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl...
Application: Analytical reference standard, structurally similar to known anabolic androgenic steroids
MW: 416.6 D
From 161.00€ *
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Misoprostol (free acid)-d5
Misoprostol (free acid)-d5

Item number: Cay10010333-50

Misoprostol (free acid)-d5 contains five deuterium atoms at the 16 methyl, 17, and 17' positions. It is intended for use as an internal standard for the quantification of misoprostol (free acid) by GC- or LC-mass spectrometry (MS). Misoprostol is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4...
Keywords: 9-oxo-11alpha,16-dihydroxy-16-(methyl-d3)-prost-13E-en-1-oic-17,17-d2 acid
Application: Standard
CAS 1337917-44-8
MW: 373.5 D
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Pravastatin (sodium salt)
Pravastatin (sodium salt)

Item number: Cay10010343-50

Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the "statin" class of cholesterol-lowering drugs. Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin. It is a competitive inhibitor...
Keywords: 1S,2S,6S,7S,8R,8aR-hexahydro-betaR,deltaR,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid,...
Application: Potent HMG-CoA reductase inhibitor
CAS 81131-70-6
MW: 446.5 D
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Lovastatin
Lovastatin

Item number: Cay10010338-50

Lovastatin is a fungal metabolite that has been found in A. terreus and an inhibitor of HMG-CoA reductase (Ki = 1.4 nM). It is also a prodrug form of the HMG-CoA reductase inhibitor lovastatin hydroxy acid (Cay-10010339). Lovastatin (8 mg/kg per day) reduces plasma cholesterol levels in dogs. It suppresses...
Keywords: 2S-methyl-butanoic acid,...
Application: NF-kappaB activation inhibitor
CAS 75330-75-5
MW: 404.5 D
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SB 202190
SB 202190

Item number: Cay10010399-50

SB 202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38alpha (SAPK2A, MAPK14) and p38beta (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. When tested at 10 µM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs,...
Keywords: 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-phenol
Application: MAP kinases Inhibitor
CAS 152121-30-7
MW: 331.3 D
From 39.00€ *
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DRB
DRB

Item number: Cay10010302-50

DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 µM), Cdk7 (IC50 = ~20 µM), Cdk8 (IC50 = ~20 µM), and Cdk9 (IC50 = 3 µM). Through inhibition of certain CTD kinases, DRB inhibits an elongation step during RNA polymerase II...
Keywords: Benzimidazole, NSC 401575, 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole
Application: CTD kinase inhibitor
CAS 53-85-0
MW: 319.1 D
From 42.00€ *
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Simvastatin
Simvastatin

Item number: Cay10010344-50

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: MK-733,...
Application: HMG-CoA reductase inhibitor
CAS 79902-63-9
MW: 418.6 D
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Fluvastatin (sodium salt hydrate)
Fluvastatin (sodium salt hydrate)

Item number: Cay10010337-50

Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Keywords: 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid, sodium salt, hydrate
Application: Hydroxymethylglutaryl-coenzyme A reductase inhibitor
MW: 410.5 D
From 35.00€ *
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Mevastatin
Mevastatin

Item number: Cay10010340-50

Mevastatin is a competitive HMG-CoA reductase inhibitor (Ki = 0.1 µM). In vivo, mevastatin (50 mg/kg) inhibits cholesterogenesis in the liver and ileum of normolipidemic rats, as well as enhances suppression of cholesterogenesis in cholesterol-fed rats or rats administered cholestyramine. Mevastatin also suppresses...
Keywords: Compactin, CS 500, L-637,312, ML 236B, NSC 281245, Statin I,...
Application: HMG-CoA reductase inhibitor
CAS 73573-88-3
MW: 390.5 D
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AG-490
AG-490

Item number: Cay10010311-50

Protein tyrosine kinase (Ptk) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of Ptks. Tyrphostins are a class of antiproliferative compounds which act as Ptk blockers. Leukemic cells from patients in relapse have constitutively activated JAK2 Ptk. AG-490 is an inhibitor of...
Keywords: Tyrphostin AG-490, (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
Application: JAK2 inhibitor
CAS 133550-30-8
MW: 294.3 D
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Protectin D1
Protectin D1

Item number: Cay10010390-50

Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA, Cay-90310). DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a...
Keywords: Neuroprotectin D1, Neuroprotectin D1/Protectin D1, NPD1, PD1, 10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid
Application: Specialized pro-resolving mediator (SPM)
CAS 660430-03-5
MW: 360.5 D
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