- Search results for Cay10010340
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4 products were found matching "Cay10010340"!
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Item number: Cay10010340-50
Mevastatin is a competitive HMG-CoA reductase inhibitor (Ki = 0.1 µM). In vivo, mevastatin (50 mg/kg) inhibits cholesterogenesis in the liver and ileum of normolipidemic rats, as well as enhances suppression of cholesterogenesis in cholesterol-fed rats or rats administered cholestyramine. Mevastatin also suppresses...
Keywords: | Compactin, CS 500, L-637,312, ML 236B, NSC 281245, Statin I,... |
Application: | HMG-CoA reductase inhibitor |
CAS | 73573-88-3 |
MW: | 390.5 D |
From 43.00€
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Item number: Cay10010343-50
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the "statin" class of cholesterol-lowering drugs. Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin. It is a competitive inhibitor...
Keywords: | 1S,2S,6S,7S,8R,8aR-hexahydro-betaR,deltaR,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid,... |
Application: | Potent HMG-CoA reductase inhibitor |
CAS | 81131-70-6 |
MW: | 446.5 D |
From 35.00€
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Item number: Cay10010344-50
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: | MK-733,... |
Application: | HMG-CoA reductase inhibitor |
CAS | 79902-63-9 |
MW: | 418.6 D |
From 43.00€
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Item number: Cay10010345-10
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-nap... |
Application: | Inhibitor of HMG-CoA reductase |
CAS | 101314-97-0 |
MW: | 458.6 D |
From 48.00€
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