4 products were found matching "Cay10010340"!

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Mevastatin
Mevastatin

Item number: Cay10010340-50

Mevastatin is a competitive HMG-CoA reductase inhibitor (Ki = 0.1 µM). In vivo, mevastatin (50 mg/kg) inhibits cholesterogenesis in the liver and ileum of normolipidemic rats, as well as enhances suppression of cholesterogenesis in cholesterol-fed rats or rats administered cholestyramine. Mevastatin also suppresses...
Keywords: Compactin, CS 500, L-637,312, ML 236B, NSC 281245, Statin I,...
Application: HMG-CoA reductase inhibitor
CAS 73573-88-3
MW: 390.5 D
From 43.00€ *
Review
Pravastatin (sodium salt)
Pravastatin (sodium salt)

Item number: Cay10010343-50

Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the "statin" class of cholesterol-lowering drugs. Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin. It is a competitive inhibitor...
Keywords: 1S,2S,6S,7S,8R,8aR-hexahydro-betaR,deltaR,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid,...
Application: Potent HMG-CoA reductase inhibitor
CAS 81131-70-6
MW: 446.5 D
From 35.00€ *
Review
Simvastatin
Simvastatin

Item number: Cay10010344-50

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: MK-733,...
Application: HMG-CoA reductase inhibitor
CAS 79902-63-9
MW: 418.6 D
From 43.00€ *
Review
Simvastatin (sodium salt)
Simvastatin (sodium salt)

Item number: Cay10010345-10

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-nap...
Application: Inhibitor of HMG-CoA reductase
CAS 101314-97-0
MW: 458.6 D
From 48.00€ *
Review