- Search results for Cay10010310
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27 products were found matching "Cay10010310"!
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Item number: Cay10010310-10
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
Keywords: | alpha-[(3,5-dichlorophenyl)methylene]-3-pyridineacetonitrile |
Application: | EGF receptor kinase inhibitor |
CAS | 136831-49-7 |
MW: | 275.1 D |
From 80.00€
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Item number: Cay10010333-100
Misoprostol (free acid)-d5 is intended for use as an internal standard for the quantification of misoprostol (free acid) (Cay-13821) by GC- or LC-MS. Misoprostol is a PGE1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50...
Keywords: | 9-oxo-11alpha,16-dihydroxy-16-(methyl-d3)-prost-13E-en-1-oic-17,17-d2 acid |
Application: | Standard |
CAS | 1337917-44-8 |
MW: | 373.5 D |
From 97.00€
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Item number: Cay10010399-10
SB 202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38alpha (SAPK2A, MAPK14) and p38beta (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. When tested at 10 µM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs,...
Keywords: | 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-phenol |
Application: | MAP kinases Inhibitor |
CAS | 152121-30-7 |
MW: | 331.3 D |
From 39.00€
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Item number: Cay10010390-10
Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA, Cay-90310). DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a...
Keywords: | Neuroprotectin D1, Neuroprotectin D1/Protectin D1, NPD1, PD1, 10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid |
Application: | Specialized pro-resolving mediator (SPM) |
CAS | 660430-03-5 |
MW: | 360.5 D |
From 163.00€
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Item number: Cay10010343-10
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the "statin" class of cholesterol-lowering drugs. Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin. It is a competitive inhibitor...
Keywords: | 1S,2S,6S,7S,8R,8aR-hexahydro-betaR,deltaR,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid,... |
Application: | Potent HMG-CoA reductase inhibitor |
CAS | 81131-70-6 |
MW: | 446.5 D |
From 35.00€
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Item number: Cay10010337-10
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Keywords: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid, sodium salt, hydrate |
Application: | Hydroxymethylglutaryl-coenzyme A reductase inhibitor |
MW: | 410.5 D |
From 35.00€
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Item number: Cay10010334-10
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Keywords: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid |
Application: | HMG-CoA reductase inhibitor |
CAS | 93957-54-1 |
MW: | 411.5 D |
From 54.00€
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Item number: Cay10010388-10
The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(4,5)-P2-fluorescein is a fluorescent probe for any protein with a high-affinity binding interaction with...
Keywords: | 1-(1-octadecanoyl-fluorescein-2R-octadecanoylphosphatidyl)inositol-4,5-bisphosphate, pentatriethylammonium salt |
Application: | Bioactive lipid assays |
MW: | 1625.8 D |
From 115.00€
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Item number: Cay10010311-50
Protein tyrosine kinase (Ptk) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of Ptks. Tyrphostins are a class of antiproliferative compounds which act as Ptk blockers. Leukemic cells from patients in relapse have constitutively activated JAK2 Ptk. AG-490 is an inhibitor of...
Keywords: | Tyrphostin AG-490, (2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide |
Application: | JAK2 inhibitor |
CAS | 133550-30-8 |
MW: | 294.3 D |
From 43.00€
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Item number: Cay10010345-10
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: | (betaR,deltaR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-1-nap... |
Application: | Inhibitor of HMG-CoA reductase |
CAS | 101314-97-0 |
MW: | 458.6 D |
From 48.00€
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Item number: Cay10010313-50
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
Keywords: | Tyrphostin 46, Tyrphostin AG-99, 2-cyano-3-(3,4-dihydroxyphenyl)-2E-propenamide |
Application: | EGF receptor kinase inhibitor |
CAS | 122520-85-8 |
MW: | 204.2 D |
From 46.00€
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Item number: Cay10010314-10
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
Keywords: | Tyrphostin 47, Tyrphostin AG-213, 2-cyano-3-(3,4-dihydroxyphenyl)-2E-propenethioamide |
Application: | EGF receptor kinase inhibitor |
CAS | 122520-86-9 |
MW: | 220.2 D |
From 77.00€
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