- Search results for Cay10010300
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18 products were found matching "Cay10010300"!
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Item number: Cay10010300-10
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as protein tryrosine kinase blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF)...
Keywords: | RG-50810, RG-50858, TX 825, Tyrphostin 23, Tyrphostin AG-18, 2-[(3,4-dihydroxyphenyl)methylene]-propanedinitrile |
Application: | EGF receptor kinase inhibitor |
CAS | 118409-57-7 |
MW: | 186.1 D |
From 46.00€
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Item number: Cay10010302-10
DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 µM), Cdk7 (IC50 = ~20 µM), Cdk8 (IC50 = ~20 µM), and Cdk9 (IC50 = 3 µM). Through inhibition of certain CTD kinases, DRB inhibits an elongation step during RNA polymerase II...
Keywords: | Benzimidazole, NSC 401575, 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole |
Application: | CTD kinase inhibitor |
CAS | 53-85-0 |
MW: | 319.1 D |
From 42.00€
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Item number: Cay10010301-10
Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising therapeutic targets for cancer and neurodegenerative diseases. Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising therapeutic targets for cancer and...
Keywords: | BML-259, N-[5-(1-methylethyl)2-thiazolyl]-benzeneacetamide |
Application: | CDK5 inhibitor, CDK2 inhibitor |
CAS | 267654-00-2 |
MW: | 260.4 D |
From 86.00€
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Item number: Cay10010309-50
Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
Keywords: | alphaZ-[(3,4-dimethoxyphenyl)methylene]-3-pyridineacetonitrile |
Application: | EGF receptor kinase inhibitor |
CAS | 149286-90-8 |
MW: | 266.3 D |
From 80.00€
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Item number: Cay10010364-100
Fatty acid binding protein 5 (FABP5) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids. Members of this protein family exhibit high affinity for lipophilic ligands and were named according to the tissue from which they were initially isolated. FABP5 is found in skin,...
Keywords: | PA-FABP, PA-FABP, E-FABP {ECO:0000303|PubMed:8092987}, E-FABP {ECO:0000303|PubMed:8092987}, Fatty acid-binding protein,... |
Application: | WB |
MW: | 18 kD |
530.00€
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Item number: Cay10010344-100
Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: | MK-733,... |
Application: | HMG-CoA reductase inhibitor |
CAS | 79902-63-9 |
MW: | 418.6 D |
From 43.00€
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Item number: Cay10010332-500
The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS). In the reverse direction, non-lysosomal glucosylceramidase (GCase), also known as beta-glucosidase 2 (BGD), cleaves the glucosyl moiety from glucosylceramide, liberating ceramide, which can be converted into...
Keywords: | Adamantane-pentyl-dNM, AMP-dNM, N-(5-adamantane-1-yl-methoxy-pentyl)-Deoxynojirimycin,... |
Application: | Glucosylceramide synthase inhibitor |
CAS | 216758-20-2 |
MW: | 397.6 D |
From 58.00€
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Item number: Cay10010337-100
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Keywords: | 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid, sodium salt, hydrate |
Application: | Hydroxymethylglutaryl-coenzyme A reductase inhibitor |
MW: | 410.5 D |
From 35.00€
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Item number: Cay10010324-500
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione (TZD) class of antidiabetic drugs. Harmine is a beta-carboline alkaloid that was first isolated from seeds of Peganum harmala (Syrian rue) and...
Keywords: | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole |
Application: | MS, beta-carboline alkaloid |
CAS | 442-51-3 |
MW: | 212.3 D |
From 43.00€
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Item number: Cay10010399-100
SB 202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38alpha (SAPK2A, MAPK14) and p38beta (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. When tested at 10 µM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs,...
Keywords: | 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-phenol |
Application: | MAP kinases Inhibitor |
CAS | 152121-30-7 |
MW: | 331.3 D |
From 39.00€
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Item number: Cay10010390-100
Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA, Cay-90310). DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a...
Keywords: | Neuroprotectin D1, Neuroprotectin D1/Protectin D1, NPD1, PD1, 10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid |
Application: | Specialized pro-resolving mediator (SPM) |
CAS | 660430-03-5 |
MW: | 360.5 D |
From 163.00€
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Item number: Cay10010340-100
Mevastatin is a competitive HMG-CoA reductase inhibitor (Ki = 0.1 µM). In vivo, mevastatin (50 mg/kg) inhibits cholesterogenesis in the liver and ileum of normolipidemic rats, as well as enhances suppression of cholesterogenesis in cholesterol-fed rats or rats administered cholestyramine. Mevastatin also suppresses...
Keywords: | Compactin, CS 500, L-637,312, ML 236B, NSC 281245, Statin I,... |
Application: | HMG-CoA reductase inhibitor |
CAS | 73573-88-3 |
MW: | 390.5 D |
From 43.00€
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