18 products were found matching "Cay10010300"!

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AG-18
AG-18

Item number: Cay10010300-10

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which act as protein tryrosine kinase blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF)...
Keywords: RG-50810, RG-50858, TX 825, Tyrphostin 23, Tyrphostin AG-18, 2-[(3,4-dihydroxyphenyl)methylene]-propanedinitrile
Application: EGF receptor kinase inhibitor
CAS 118409-57-7
MW: 186.1 D
From 46.00€ *
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DRB
DRB

Item number: Cay10010302-10

DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 µM), Cdk7 (IC50 = ~20 µM), Cdk8 (IC50 = ~20 µM), and Cdk9 (IC50 = 3 µM). Through inhibition of certain CTD kinases, DRB inhibits an elongation step during RNA polymerase II...
Keywords: Benzimidazole, NSC 401575, 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole
Application: CTD kinase inhibitor
CAS 53-85-0
MW: 319.1 D
From 42.00€ *
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CAY10554
CAY10554

Item number: Cay10010301-10

Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising therapeutic targets for cancer and neurodegenerative diseases. Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising therapeutic targets for cancer and...
Keywords: BML-259, N-[5-(1-methylethyl)2-thiazolyl]-benzeneacetamide
Application: CDK5 inhibitor, CDK2 inhibitor
CAS 267654-00-2
MW: 260.4 D
From 86.00€ *
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RG-13022
RG-13022

Item number: Cay10010309-50

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors that preferentially inhibit the epidermal growth factor (EGF) receptor kinase block...
Keywords: alphaZ-[(3,4-dimethoxyphenyl)methylene]-3-pyridineacetonitrile
Application: EGF receptor kinase inhibitor
CAS 149286-90-8
MW: 266.3 D
From 80.00€ *
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FABP5 (human, recombinant)
FABP5 (human, recombinant)

Item number: Cay10010364-100

Fatty acid binding protein 5 (FABP5) is one of nine known cytosolic FABPs ranging in size from 14-15 kDa containing 127-132 amino acids. Members of this protein family exhibit high affinity for lipophilic ligands and were named according to the tissue from which they were initially isolated. FABP5 is found in skin,...
Keywords: PA-FABP, PA-FABP, E-FABP {ECO:0000303|PubMed:8092987}, E-FABP {ECO:0000303|PubMed:8092987}, Fatty acid-binding protein,...
Application: WB
MW: 18 kD
530.00€ *
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Simvastatin
Simvastatin

Item number: Cay10010344-100

Simvastatin is a competitive inhibitor of HMG-CoA reductase (Ki = 0.12 nM). Simvastatin reduces plasma cholesterol levels in rats and dogs when administered at doses of 1.2 and 8 mg/kg, respectively. Simvastatin suppresses TNF-induced NF-kappaB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid...
Keywords: MK-733,...
Application: HMG-CoA reductase inhibitor
CAS 79902-63-9
MW: 418.6 D
From 43.00€ *
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AMP-Deoxynojirimycin
AMP-Deoxynojirimycin

Item number: Cay10010332-500

The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS). In the reverse direction, non-lysosomal glucosylceramidase (GCase), also known as beta-glucosidase 2 (BGD), cleaves the glucosyl moiety from glucosylceramide, liberating ceramide, which can be converted into...
Keywords: Adamantane-pentyl-dNM, AMP-dNM, N-(5-adamantane-1-yl-methoxy-pentyl)-Deoxynojirimycin,...
Application: Glucosylceramide synthase inhibitor
CAS 216758-20-2
MW: 397.6 D
From 58.00€ *
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Fluvastatin (sodium salt hydrate)
Fluvastatin (sodium salt hydrate)

Item number: Cay10010337-100

Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc-...
Keywords: 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid, sodium salt, hydrate
Application: Hydroxymethylglutaryl-coenzyme A reductase inhibitor
MW: 410.5 D
From 35.00€ *
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Harmine
Harmine

Item number: Cay10010324-500

Peroxisome proliferator-activated receptor gamma (PPARgamma) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione (TZD) class of antidiabetic drugs. Harmine is a beta-carboline alkaloid that was first isolated from seeds of Peganum harmala (Syrian rue) and...
Keywords: 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
Application: MS, beta-carboline alkaloid
CAS 442-51-3
MW: 212.3 D
From 43.00€ *
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SB 202190
SB 202190

Item number: Cay10010399-100

SB 202190 is a selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38alpha (SAPK2A, MAPK14) and p38beta (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. When tested at 10 µM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs,...
Keywords: 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-phenol
Application: MAP kinases Inhibitor
CAS 152121-30-7
MW: 331.3 D
From 39.00€ *
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Protectin D1
Protectin D1

Item number: Cay10010390-100

Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA, Cay-90310). DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a...
Keywords: Neuroprotectin D1, Neuroprotectin D1/Protectin D1, NPD1, PD1, 10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid
Application: Specialized pro-resolving mediator (SPM)
CAS 660430-03-5
MW: 360.5 D
From 163.00€ *
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Mevastatin
Mevastatin

Item number: Cay10010340-100

Mevastatin is a competitive HMG-CoA reductase inhibitor (Ki = 0.1 µM). In vivo, mevastatin (50 mg/kg) inhibits cholesterogenesis in the liver and ileum of normolipidemic rats, as well as enhances suppression of cholesterogenesis in cholesterol-fed rats or rats administered cholestyramine. Mevastatin also suppresses...
Keywords: Compactin, CS 500, L-637,312, ML 236B, NSC 281245, Statin I,...
Application: HMG-CoA reductase inhibitor
CAS 73573-88-3
MW: 390.5 D
From 43.00€ *
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