16 products were found matching "Cay10010279"!

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D2 (RvD2) is produced...

Formulation: A lyophilized powder.

(E/Z)-Belinostat is a racemic form of the class I and II histone deacetylase (HDAC) inhibitor belinostat (Cay-34084).Formal Name: N-hydroxy-3-[3-[(phenylamino)sulfonyl]phenyl]-2-propenamide. CAS Number: 414864-00-9. Synonyms: (E/Z)-PXD 101, (E/Z)-PX 105684. Molecular Formula: C15H14N2O4S. Formula Weight: 318.3....

Platelet-activating factor (PAF) is an important lipid mediator involved in inflammation. PAF-acetylhydrolase (PAF-AH) is an extracellular phospholipase A2 which hydrolyzes the acetyl group at the sn-2 position of phospholipids. Two main types of PAF-AH have been characterized, namely the secreted (i.e. plasma) and...

Sterol O-acyltransferase 2 (SOAT-2), also known as acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2), is an enzyme encoded by ACAT2 in humans that catalyzes the intracellular formation of cholesterol esters from cholesterol and long-chain fatty acyl-coenzyme A. It is constitutively expressed in the liver and...

Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 µM apigenin decreases the...

Bupropion-d9 (hydrochloride) (Cay-10010679) is an analytical reference material intended for use as an internal standard for the quantification of bupropion (Cay-10488) by GC- or LC-MS. Bupropion is categorized as an antidepressant. It is also useful in promoting smoking cessation. This product is intended for...

Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn-2 hydroxy group forms a 5-membered ring with the sn-3 phosphate. Carba-derivatives of cPA (ccPA) are modified at the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, preventing the opening of cPA to produce...

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for...

Arbaprostil (15(R)-15-methyl prostaglandin E2) is a synthetic prostaglandin E2 (PGE2) analog developed for its cytoprotective activity. 15(R)-15-methyl Prostaglandin A2 (15(R)-15-methyl PGA2) is one of several impurities which are possible in the production of commercial lots of bulk arbaprostil. The pharmacology...

PAF C-18-d4 contains four deuterium atoms at the 9, 9', 10, and 10' positions. It is intended for use as an internal standard for the quantification of PAF C-18 by GC- or LC-mass spectrometry. PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the...

The development of selective, cell-permeable protein kinase inhibitors for the treatment of cancer, inflammation, and other diseases, is a major focus of drug development efforts. Kenpaullone is an ATP-competitive inhibitor of several cyclin-dependent kinases (CDKs) as well as glycogen synthase kinase 3beta...