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LFM-A13 | CAS 244240-24-2

ART NR.: Cay10010265-5 (5 mg)
Cay10010265-10 (10 mg)
Cay10010265-50 (50 mg)
Cay10010265-100 (100 mg)

Hersteller: Cayman

Datenblatt



MSDS

Anwendungen: Tyrosine kinase inhibitor

CAS-Nr. : 244240-​24-​2
Suche mit CAS-Nr.

MW: 360 D

Formel: C11H8Br2N2O2

Reinheit: >98%

Format: crystalline solid

Lagerung: -20°C

Versand: -20°C

Schlagworte: 2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide

Cay10010265-5

5 mg

64 €

Cay10010265-10

10 mg

122 €

Cay10010265-50

50 mg

510 €

Cay10010265-100

100 mg

893 €

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Bemerkungen: LFM-A13 is an anti-leukemia agent with apoptosis-promoting and chemosensitizing properties. It acts as an inhibitor of Bruton · s tyrosine kinase (BTK) and Polo-like kinase (Plk) with IC50 values of 2.5 µM (murine recombinant) and 10 µM (Xenopus), respectively. LFM-A13 exhibits minor inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and CDK1, 2 and 3, as well as several other related kinases. LFM-A13 also exhibits anti-proliferative activity against Her2/Neu-overexpressing breast cancer cells.
Image Art Cay10010265-50 Cayman LFM-A13

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