8 products were found matching "Cay10010265"!

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LFM-A13
LFM-A13

Item number: Cay10010265-5

LFM-A13 is an inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 2.5 µM). It is selective for BTK over JAK1, JAK3, IRK, EGFR, and HCK (IC50s = >278 µM for all), as well as a panel of seven serine/threonine and 10 tyrosine kinases as well as one lipid kinase (IC50s = >200-500 µM), but does inhibit polo-like kinase 3...
Keywords: 2Z-cyano-N-(2,5-dibromophenyl)3-hydroxy-2-butenamide
Application: Tyrosine kinase inhibitor
CAS 244240-24-2
MW: 360 D
From 92.00€ *
Review
BAY 11-7082
BAY 11-7082

Item number: Cay10010266-5

The transcription factor NF-kappaB plays a key role in regulating over 150 target genes including the expression of inflammatory cytokines, chemokines, immunoreceptors, and cell adhesion molecules. In the cytoplasm, inactive NF-kappaB complexes are bound to an inhibitor IkappaB. However in response to certain...
Keywords: 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile
Application: NF-kappaB activation inhibitor
CAS 19542-67-7
MW: 207.3 D
From 66.00€ *
Review
BMS309403
BMS309403

Item number: Cay10010206-5

Fatty acid binding protein 4 (FABP4) is a lipid transport protein that is also known as adipocyte FABP and aP2. In addition to adipocytes, it is also abundant in macrophages, along with FABP5, the epidermal FABP. BMS309403 is a cell-permeable, potent inhibitor of FABP4 that targets the fatty acid-binding pocket (Ki...
Keywords: A-FABP Inhibitor, Adipocyte FABP Inhibitor, ALBP Inhibitor, aP2 Inhibitor, FABP4 Inhibitor, Fatty Acid Binding Protein 4...
Application: Cell-permeable, potent FABP4 inhibitor
CAS 300657-03-8
MW: 474.6 D
From 60.00€ *
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SC-514
SC-514

Item number: Cay10010267-5

SC-514 is a selective and reversible inhibitor of IkappaB kinase 2 (IKK2) (IC50 = 3-12 µM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. In synovial fibroblasts stimulated with interleukin (IL)-1beta, SC-514 attenuates NF-kappaB-mediated expression of IL-6,...
Keywords: 4-amino-[2,3'-bithiophene]-5-carboxamide
Application: IKK2 inhibitor
CAS 354812-17-2
MW: 224.3 D
From 60.00€ *
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Lavendustin A
Lavendustin A

Item number: Cay10010268-5

Lavendustin A is a selective inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase (IC50 = 11 nM) that was first isolated from a Streptomyces culture filtrate. It does not inhibit protein kinase A (PKA), PKC, or PI3K (IC50s > 100 µM). It has been used to differentiate rat mesenchymal stem...
Keywords: NSC 678027, RG-14355, 5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-benzoic acid
Application: EGFR inhibitor
CAS 125697-92-9
MW: 381.4 D
From 109.00€ *
Review
KRP 203
KRP 203

Item number: Cay10010426-5

KRP 203 is a sphingosine-1-phosphate receptor 1 (S1P1) agonist. It selectively induces calcium mobilization in CHO-K1 cells expressing mouse S1P1 over mouse S1P3 and S1P4 (EC50s = 0.84, >1,000, and 9.61 nM, respectively). In vivo, KRP 203 (0.3 mg/kg) prevents the development of wasting syndrome, decreases diarrhea...
Keywords: Mocravimod (hydrochloride), 2-amino-2-[2-[2-chloro-4-[[3-(phenylmethoxy)phenyl]thio]phenyl]ethyl]-1,3-propanediol,...
Application: S1P1 receptor agonist
CAS 509088-69-1
MW: 480.4 D
From 68.00€ *
Review
SB-216763
SB-216763

Item number: Cay10010246-5

Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli including insulin, growth factors, cell specification factors, and cell adhesion. SB-216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3alpha with an IC50...
Keywords: 3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Application: GSK inhibitor
CAS 280744-09-4
MW: 371.2 D
From 98.00€ *
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CAY10563
CAY10563

Item number: Cay10010526-5

S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO)....
Keywords: 4-(p-trifluoromethylphenyl)-1,3,2-Oxathiazolylium-5-olate, 4-trifluoro-4-phenyl-1,3,2-oxathiazolidine-5-one
Application: NO donor
MW: 249.2 D
From 43.00€ *
Review